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Effect of f68 on cryopreservation of mesenchymal stem cells derived from human tooth germ

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dc.contributor.author Doǧan A.
dc.contributor.author Yalvaç M.
dc.contributor.author Yilmaz A.
dc.contributor.author Rizvanov A.
dc.contributor.author Şahin F.
dc.date.accessioned 2018-09-18T20:07:44Z
dc.date.available 2018-09-18T20:07:44Z
dc.date.issued 2013
dc.identifier.issn 0273-2289
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/136785
dc.description.abstract The use of stem-cell-based therapies in regenerative medicine and in the treatment of disorders such as Parkinson, Alzheimer's disease, diabetes, spinal cord injuries, and cancer has been shown to be promising. Among all stem cells, mesenchymal stem cells (MSCs) were reported to have anti-apoptotic, immunomodulatory, and angiogenic effects which are attributed to the restorative capacity of these cells. Human tooth germ stem cells (HTGSCs) having mesenchymal stem cell characteristics have been proven to exert high proliferation and differentiation capacity. Unlike bone-marrow-derived MSCs, HTGSCs can be easily isolated, expanded, and cryopreserved, which makes them an alternative stem cell source. Regardless of their sources, the stem cells are exposed to physical and chemical stresses during cryopreservation, hindering their therapeutic capacity. Amelioration of the side effects of cryopreservation on MSCs seems to be a priority in order to maximize the therapeutic efficacy of these cells. In this study, we tested the effect of Pluronic 188 (F68) on HTGSCs during long-term cryopreservation and repeated freezing and defrosting cycles. Our data revealed that F68 has a protective role on survival and differentiation of HTGSCs in long-term cryopreservation. © 2013 Springer Science+Business Media New York.
dc.relation.ispartofseries Applied Biochemistry and Biotechnology
dc.subject Cryopreservation
dc.subject Human tooth germ stem cell
dc.subject Pluronic
dc.title Effect of f68 on cryopreservation of mesenchymal stem cells derived from human tooth germ
dc.type Article
dc.relation.ispartofseries-issue 7
dc.relation.ispartofseries-volume 171
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 1819
dc.source.id SCOPUS02732289-2013-171-7-SID84890557175


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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