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Effects of hydrogen sulfide on the processes of exo- and endocytosis of synaptic vesicles in mouse motor nerve endings

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dc.contributor.author Mitrukhina O.
dc.contributor.author Yakovlev A.
dc.contributor.author Sitdikova G.
dc.date.accessioned 2018-09-18T20:07:21Z
dc.date.available 2018-09-18T20:07:21Z
dc.date.issued 2012
dc.identifier.issn 0233-4755
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/136716
dc.description.abstract The effects of sodium hydrosulfide(NaHS),the donor of hydrogen sulfide(H2S),on the exo-endocytosis cycle of the synaptic vesicles in the motor nerve ending of mouse diaphragm were explored using intracellular microelectrode technique and fluorescent microscopy. NaHS increased the frequency of miniature end-plate potentials(MEPPs) without changing its amplitude-time parameters and the amplitude of the postsynaptic responses undersingle stimulus condition(0.3 Hz),giving evidence on enhancing synaptic vesicle exocytosis. During high-frequency stimulation(50 Hz) NaHS induced more significant decline of neurotransmitter secretion,which can be due to the lower rate of synaptic vesicle mobilization from the recycling pool to the exocytic cites. NaHS also decreased the uptake of the fluorescent endocytic dye FM 1-43, which indicates the reduced endocytosis of the synaptic vesicles. Thus,the donor of H2S increased exocytosis and decreased the processes of the synaptic vesicles' endocytosis and mobilization in the mouse motor nerve ending.
dc.relation.ispartofseries Biologicheskie Membrany
dc.title Effects of hydrogen sulfide on the processes of exo- and endocytosis of synaptic vesicles in mouse motor nerve endings
dc.type Article
dc.relation.ispartofseries-issue 5
dc.relation.ispartofseries-volume 29
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 324
dc.source.id SCOPUS02334755-2012-29-5-SID84881420582


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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