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Structural transformations during swelling of polycomplex matrices based on countercharged (meth)acrylate copolymers (Eudragit® EPO/Eudragit® L 100-55)

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dc.contributor.author Moustafine R.
dc.contributor.author Bobyleva V.
dc.contributor.author Bukhovets A.
dc.contributor.author Garipova V.
dc.contributor.author Kabanova T.
dc.contributor.author Kemenova V.
dc.contributor.author Van Den Mooter G.
dc.date.accessioned 2018-09-18T20:05:31Z
dc.date.available 2018-09-18T20:05:31Z
dc.date.issued 2011
dc.identifier.issn 0022-3549
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/136424
dc.description.abstract With a view to the application in oral controlled drug delivery systems (DDS), the design of new interpolyelectrolyte complexes (IPECs) between countercharged types of Eudragit® EPO (EPO) and Eudragit® L 100-55 (L100-55) was investigated. The formation and composition of four new IPECs between EPO and L100-55 were established by elementary analysis. The structure of the synthesized IPEC was investigated using FTIR spectroscopy and modulated-temperature differential scanning calorimetry. The binding ratio of a unit molecule of EPO with L100-55 was found to range between 1:2.75 (Z = 0.36) and 1:0.55 (Z = 1.81) while increasing the pH value from 5.5 to 7.0. As a result of electrostatic interaction between the copolymer chains, the glass transition temperature of the IPEC increased significantly. A large pH-sensitive swelling behavior was observed for different structures of the IPECs. The outcome of swelling and diclofenac sodium release from the polycomplex matrices confirm that they have great potential to be used as a controlled DDS in specified regions of gastrointestinal tract. © 2010 Wiley-Liss, Inc. and the American Pharmacists Association.
dc.relation.ispartofseries Journal of Pharmaceutical Sciences
dc.subject Controlled release
dc.subject Diclofenac sodium
dc.subject Eudragit® EPO
dc.subject Eudragit® L 100-55
dc.subject FTIR; glass transition
dc.subject Interpolyelectrolyte complexes
dc.subject Oral drug delivery
dc.subject PH-dependent swelling behavior
dc.subject Polymeric drug carrier
dc.title Structural transformations during swelling of polycomplex matrices based on countercharged (meth)acrylate copolymers (Eudragit® EPO/Eudragit® L 100-55)
dc.type Article
dc.relation.ispartofseries-issue 3
dc.relation.ispartofseries-volume 100
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 874
dc.source.id SCOPUS00223549-2011-100-3-SID79251564913

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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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