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Inhibition of biofilm formation in Bacillus subtilis by new halogenated furanones

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dc.contributor.author Kayumov A.
dc.contributor.author Khakimullina E.
dc.contributor.author Sharafutdinov I.
dc.contributor.author Trizna E.
dc.contributor.author Latypova L.
dc.contributor.author Thi Lien H.
dc.contributor.author Margulis A.
dc.contributor.author Bogachev M.
dc.contributor.author Kurbangalieva A.
dc.date.accessioned 2018-09-18T20:04:31Z
dc.date.available 2018-09-18T20:04:31Z
dc.date.issued 2015
dc.identifier.issn 0021-8820
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/136256
dc.description.abstract © 2015 Japan Antibiotics Research Association All rights reserved. Gram-positive bacteria can cause various infections including hospital-acquired infections. While in the biofilm, the resistance of bacteria to both antibiotics and the human immune system is increased causing difficulties in the treatment. Bacillus subtilis, a non-pathogenic Gram-positive bacterium, is widely used as a model organism for studying biofilm formation. Here we investigated the effect of novel synthesized chloro- and bromo-containing 2(5H)-furanones on biofilm formation by B. subtilis. Mucobromic acid (3,4-dibromo-5-hydroxy-2(5H)-furanone) and the two derivatives of mucochloric acid (3,4-dichloro-5-hydroxy-2(5H)-furanone) - F8 and F12 - were found to inhibit the growth and to efficiently prevent biofilm formation by B. subtilis. Along with the low production of polysaccharide matrix and repression of the eps operon, strong repression of biofilm-related yqxM also occurred in the presence of furanones. Therefore, our data confirm that furanones affect significantly the regulatory pathway(s) leading to biofilm formation. We propose that the global regulator, Spo0A, is one of the potential putative cellular targets for these compounds.
dc.relation.ispartofseries Journal of Antibiotics
dc.title Inhibition of biofilm formation in Bacillus subtilis by new halogenated furanones
dc.type Article
dc.relation.ispartofseries-issue 5
dc.relation.ispartofseries-volume 68
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 297
dc.source.id SCOPUS00218820-2015-68-5-SID84930207225


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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