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Transcription factor TnrA inhibits the biosynthetic activity of glutamine synthetase in Bacillus subtilis

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dc.contributor.author Fedorova K.
dc.contributor.author Kayumov A.
dc.contributor.author Woyda K.
dc.contributor.author Ilinskaja O.
dc.contributor.author Forchhammer K.
dc.date.accessioned 2018-09-18T20:03:34Z
dc.date.available 2018-09-18T20:03:34Z
dc.date.issued 2013
dc.identifier.issn 0014-5793
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/136122
dc.description.abstract The Bacillus subtilis glutamine synthetase (GS) plays a dual role in cell metabolism by functioning as catalyst and regulator. GS catalyses the ATP-dependent synthesis of glutamine from glutamate and ammonium. Under nitrogen-rich conditions, GS becomes feedback-inhibited by high intracellular glutamine levels and then binds transcription factors GlnR and TnrA, which control the genes of nitrogen assimilation. While GS-bound TnrA is no longer able to interact with DNA, GlnR-DNA binding is shown to be stimulated by GS complex formation. In this paper we show a new physiological feature of the interaction between glutamine synthetase and TnrA. The transcription factor TnrA inhibits the biosynthetic activity of glutamine synthetase in vivo and in vitro, while the GlnR protein does not affect the activity of the enzyme. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
dc.relation.ispartofseries FEBS Letters
dc.subject Bacillus subtilis
dc.subject Glutamine synthetase
dc.subject Nitrogen regulation
dc.subject Transcription factor TnrA
dc.title Transcription factor TnrA inhibits the biosynthetic activity of glutamine synthetase in Bacillus subtilis
dc.type Article
dc.relation.ispartofseries-issue 9
dc.relation.ispartofseries-volume 587
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 1293
dc.source.id SCOPUS00145793-2013-587-9-SID84876476663


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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