Effect of NO Synthase Blockade on NO Production in Rat Heart under Conditions of Hypokinesia

dc.contributor.author	Zaripova R.
dc.contributor.author	Gainutdinov K.
dc.contributor.author	Zefirov T.
dc.date.accessioned	2018-09-18T20:02:28Z
dc.date.available	2018-09-18T20:02:28Z
dc.date.issued	2014
dc.identifier.issn	0007-4888
dc.identifier.uri	https://dspace.kpfu.ru/xmlui/handle/net/135988
dc.description.abstract	© 2014, Springer Science+Business Media New York. Electron paramagnetic (EPR) spectroscopy study showed that 90-day hypokinesia in rats is accompanied by an increase in NO production in the heart. A nonselective NO synthase inhibitor L-NAME decreased the content of NO in the heart atria and ventricles of hypokinetic rats by 67-70%. A selective inhibitor of inducible NO synthase, aminoguanidine, also decreased the level of NO in the heart atria and ventricles of hypokinetic rats by 60-65%. Our results indicate that the increase in NO production during hypokinesia is associated with activation of NO synthases.
dc.relation.ispartofseries	Bulletin of Experimental Biology and Medicine
dc.subject	electron paramagnetic resonance
dc.subject	heart
dc.subject	hypokinesia
dc.subject	NO
dc.subject	rat
dc.title	Effect of NO Synthase Blockade on NO Production in Rat Heart under Conditions of Hypokinesia
dc.type	Article
dc.relation.ispartofseries-issue	5
dc.relation.ispartofseries-volume	157
dc.collection	Публикации сотрудников КФУ
dc.relation.startpage	545
dc.source.id	SCOPUS00074888-2014-157-5-SID84921938891

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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.