Kazan Federal University Digital Repository

Role of ryanodine receptors in the effects of hydrogen sulfide on transmitter release from the frog motor nerve ending

Show simple item record

dc.contributor.author Gerasimova E.
dc.contributor.author Yakovleva O.
dc.contributor.author Zefirov A.
dc.contributor.author Sitdikova G.
dc.date.accessioned 2018-09-18T20:02:24Z
dc.date.available 2018-09-18T20:02:24Z
dc.date.issued 2013
dc.identifier.issn 0007-4888
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/135977
dc.description.abstract We studied the role of ryanodine receptors in the effects of hydrogen sulfide on transmitter release from frog motor nerve ending. Sodium hydrosulfide (300 μM), a donor of hydrogen sulfide, reversibly increased the frequency of miniature endplate current without changes in its amplitude-time parameters. These effects were associated with reversible increase in endplate current amplitude, which was abolished by activation of ryanodine receptors of intracellular Ca2+ stores with caffeine (3 mM) and ryanodine (0.5 μM). Under conditions of ryanodine receptors blockade with ryanodine (10 μM), sodium hydrosulfide had no effect on induced transmitter release, but its effects remained unchanged during ryanodine receptors blockade with dantrolene (25 μM). We concluded that an enhanced acetylcholine release induced by hydrogen sulfide is related to an increase of intracellular Ca 2+ concentration due to activation of ryanodine receptors for intracellular Ca2+-pool. © 2013 Springer Science+Business Media New York.
dc.relation.ispartofseries Bulletin of Experimental Biology and Medicine
dc.subject hydrogen sulfide
dc.subject myoneural junction
dc.subject ryanodine receptors
dc.subject transmitter secretion
dc.title Role of ryanodine receptors in the effects of hydrogen sulfide on transmitter release from the frog motor nerve ending
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 155
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 11
dc.source.id SCOPUS00074888-2013-155-1-SID84879921347


Files in this item

This item appears in the following Collection(s)

  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics