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Role of calcium and potassium channels in effects of hydrogen sulfide on frog myocardial contractility

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dc.contributor.author Sitdikova G.
dc.contributor.author Khaertdinov N.
dc.contributor.author Zefirov A.
dc.date.accessioned 2018-09-18T20:02:20Z
dc.date.available 2018-09-18T20:02:20Z
dc.date.issued 2011
dc.identifier.issn 0007-4888
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/135966
dc.description.abstract The effects of sodium hydrosulfide NaHS, a donor of hydrogen sulfide H 2S, on the force of muscle contraction were examined on isolated myocardial strips from frog ventricles. NaHS decreased the amplitude of muscle contractions in a dose-dependent manner under normal conditions and during inhibition of Ca channels with nifedipine. In contrast, under conditions of blockade of ATP-dependent potassium channels with glibenclamide, NaHS exerted a positive inotropic effect from the first minute of application. Neither blockade, nor activation of ATP-dependent K-channels with glibenclamide modulated the negative inotropic effect of NaHS. Inhibition of K-channels with tetraethylammonium (TEA) (3, 5, 10 mM) or 4-aminopyridine increased the amplitude of myocardial contractions. Preliminary application of 4-aminopyridine or TEA (3 mM) did not eliminate NaHS-induced negative inotropic effect, although higher TEA concentrations (5 or 10 mM) prevented it. The data indicate that the targets of H2S in frog myocardium are ATP-dependent, Ca-activated, and voltage-dependent K-channels. © 2011 Springer Science+Business Media, Inc.
dc.relation.ispartofseries Bulletin of Experimental Biology and Medicine
dc.subject ATP-dependent K-channels
dc.subject Ca-activated K-channels
dc.subject calcium channels
dc.subject frog myocardium
dc.subject hydrogen sulfide
dc.subject voltage-dependent K-channels
dc.title Role of calcium and potassium channels in effects of hydrogen sulfide on frog myocardial contractility
dc.type Article
dc.relation.ispartofseries-issue 2
dc.relation.ispartofseries-volume 151
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 163
dc.source.id SCOPUS00074888-2011-151-2-SID79959553454


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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