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dc.contributor.author | Zverev A. | |
dc.contributor.author | Anikina T. | |
dc.contributor.author | Sitdicov F. | |
dc.date.accessioned | 2018-09-18T20:02:19Z | |
dc.date.available | 2018-09-18T20:02:19Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0007-4888 | |
dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/135962 | |
dc.description.abstract | Experiments with selective agonists and antagonists of purinoceptors allowed us to evaluate the subtype of P2X receptors. We showed that the myocardium of 14-100-day-old rats contains functionally active P2X 1 receptors. These receptors are involved in the realization of the positive inotropic effect of the atria and ventricles. Selective P2X 1 receptor agonist β,γ-methylene-ATP induced a dose-dependent increase in the strength of atrial and ventricular contractions. P2X 1 receptor antagonist TNP-ATP abolished the effect of the agonist in rats of all age groups. © Springer Science+Business Media, Inc. 2008. | |
dc.relation.ispartofseries | Bulletin of Experimental Biology and Medicine | |
dc.subject | Myocardial contractility | |
dc.subject | Ontogeny | |
dc.subject | P2X receptors | |
dc.title | Role of P2X receptors in positive inotropic effect of rat myocardium during ontogeny | |
dc.type | Article | |
dc.relation.ispartofseries-issue | 2 | |
dc.relation.ispartofseries-volume | 145 | |
dc.collection | Публикации сотрудников КФУ | |
dc.relation.startpage | 174 | |
dc.source.id | SCOPUS00074888-2008-145-2-SID50649104575 |