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Activation of spinal locomotor circuits in the decerebrated cat by spinal epidural and/or intraspinal electrical stimulation

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dc.contributor.author Lavrov I.
dc.contributor.author Musienko P.
dc.contributor.author Selionov V.
dc.contributor.author Zdunowski S.
dc.contributor.author Roy R.
dc.contributor.author Reggie Edgerton V.
dc.contributor.author Gerasimenko Y.
dc.date.accessioned 2018-09-18T20:02:14Z
dc.date.available 2018-09-18T20:02:14Z
dc.date.issued 2015
dc.identifier.issn 0006-8993
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/135950
dc.description.abstract The present study was designed to further compare the stepping-like movements generated via epidural (ES) and/or intraspinal (IS) stimulation. We examined the ability to generate stepping-like movements in response to ES and/or IS of spinal lumbar segments L1-L7 in decerebrate cats. ES (5-10 Hz) of the dorsal surface of the spinal cord at L3-L7 induced hindlimb stepping-like movements on a moving treadmill belt, but with no rhythmic activity in the forelimbs. IS (60 Hz) of the dorsolateral funiculus at L1-L3 (depth of 0.5-1.0 mm from the dorsal surface of the spinal cord) induced quadrupedal stepping-like movements. Forelimb movements appeared first, followed by stepping-like movements in the hindlimbs. ES and IS simultaneously enhanced the rhythmic performance of the hindlimbs more robustly than ES or IS alone. The differences in the stimulation parameters, site of stimulation, and motor outputs observed during ES vs. IS suggest that different neural mechanisms were activated to induce stepping-like movements. The effects of ES may be mediated more via dorsal structures in the lumbosacral region of the spinal cord, whereas the effects of IS may be mediated via more ventral propriospinal networks and/or brainstem locomotor areas. Furthermore, the more effective facilitation of the motor output during simultaneous ES and IS may reflect some convergence of pathways on the same interneuronal populations involved in the regulation of locomotion.
dc.relation.ispartofseries Brain Research
dc.subject Decerebrate cat
dc.subject Epidural stimulation
dc.subject Intraspinal stimulation
dc.subject Locomotion
dc.subject Spinal cord
dc.title Activation of spinal locomotor circuits in the decerebrated cat by spinal epidural and/or intraspinal electrical stimulation
dc.type Article
dc.relation.ispartofseries-volume 1600
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 84
dc.source.id SCOPUS00068993-2015-1600-SID84923603400


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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