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Sphingomyelin structure influences the lateral diffusion and raft formation in lipid bilayers

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dc.contributor.author Filippov A.
dc.contributor.author Orädd G.
dc.contributor.author Lindblom G.
dc.date.accessioned 2018-09-18T20:02:09Z
dc.date.available 2018-09-18T20:02:09Z
dc.date.issued 2006
dc.identifier.issn 0006-3495
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/135937
dc.description.abstract Liquid-disordered/liquid-ordered two-phase coexistence regions in hydrated bilayers have been investigated for sphingomyelins (SMs) of three different origins: egg, brain, and milk with the pulsed-field gradient NMR technique for lateral diffusion measurement. It is found that the three SMs have the same diffusional behavior in bilayers of SM alone, but in the multicomponent systems of dioleoylphosphatidylcholine/SM/cholesterol, the ability to form domains differs for the three SMs. The two-phase area is more extended for eggSMthan for brain SM, and no two-phase coexistence is found for milk SM. The differences in behavior are correlated with the homogeneity of the SM hydrocarbon chain compositions, in which egg SM has the most homogeneous and milk SM has the most heterogeneous composition. The results indicate that a crucial element in the domain-forming process is the formation of highly packed bilayers of SM and cholesterol rather than specific interactions between SM and cholesterol. © 2006 by the Biophysical Society.
dc.relation.ispartofseries Biophysical Journal
dc.title Sphingomyelin structure influences the lateral diffusion and raft formation in lipid bilayers
dc.type Article
dc.relation.ispartofseries-issue 6
dc.relation.ispartofseries-volume 90
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 2086
dc.source.id SCOPUS00063495-2006-90-6-SID33645992493


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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