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Mechanism of action of DNA-hydrolyzing antibodies to DNA from blood of patients with systemic lupus erythematosus

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dc.contributor.author Nevzorova T.
dc.contributor.author Vinter V.
dc.contributor.author Konovalova O.
dc.contributor.author Salakhov M.
dc.date.accessioned 2018-09-18T20:02:04Z
dc.date.available 2018-09-18T20:02:04Z
dc.date.issued 2006
dc.identifier.issn 0006-2979
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/135923
dc.description.abstract Four fractions of IgG antibodies to native DNA (nDNA) were obtained from blood of patients with systemic lupus erythematosus. These antibodies displayed a thermostable DNA-hydrolyzing activity and were different in affinity for DNA-cellulose and sorption on DEAE-cellulose. DNA-hydrolyzing antibodies to nDNA are metal-dependent endonucleases, cause mainly single-strand breaks in DNA, and are active over a wide range of pH. By atomic-force microscopy, three-dimensional images of DNA complexes with DNA-hydrolyzing antibodies to nDNA were obtained with nanometer resolution, and a nonprocessive action mechanism was shown for the DNase activity of antibodies to nDNA. © Nauka/Interperiodica 2006.
dc.relation.ispartofseries Biochemistry (Moscow)
dc.subject Abzymes
dc.subject Atomic-force microscopy
dc.subject Hydrolysis of DNA
dc.subject IgG
dc.subject Polyclonal catalytic antibodies
dc.subject Systemic lupus erythematosus
dc.title Mechanism of action of DNA-hydrolyzing antibodies to DNA from blood of patients with systemic lupus erythematosus
dc.type Article
dc.relation.ispartofseries-issue 11
dc.relation.ispartofseries-volume 71
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 1238
dc.source.id SCOPUS00062979-2006-71-11-SID33751511799


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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