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Mechanism of action of DNA-hydrolyzing antibodies to DNA from blood of patients with systemic lupus erythematosus
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| dc.contributor.author | Nevzorova T. | |
| dc.contributor.author | Vinter V. | |
| dc.contributor.author | Konovalova O. | |
| dc.contributor.author | Salakhov M. | |
| dc.date.accessioned | 2018-09-18T20:02:04Z | |
| dc.date.available | 2018-09-18T20:02:04Z | |
| dc.date.issued | 2006 | |
| dc.identifier.issn | 0006-2979 | |
| dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/135923 | |
| dc.description.abstract | Four fractions of IgG antibodies to native DNA (nDNA) were obtained from blood of patients with systemic lupus erythematosus. These antibodies displayed a thermostable DNA-hydrolyzing activity and were different in affinity for DNA-cellulose and sorption on DEAE-cellulose. DNA-hydrolyzing antibodies to nDNA are metal-dependent endonucleases, cause mainly single-strand breaks in DNA, and are active over a wide range of pH. By atomic-force microscopy, three-dimensional images of DNA complexes with DNA-hydrolyzing antibodies to nDNA were obtained with nanometer resolution, and a nonprocessive action mechanism was shown for the DNase activity of antibodies to nDNA. © Nauka/Interperiodica 2006. | |
| dc.relation.ispartofseries | Biochemistry (Moscow) | |
| dc.subject | Abzymes | |
| dc.subject | Atomic-force microscopy | |
| dc.subject | Hydrolysis of DNA | |
| dc.subject | IgG | |
| dc.subject | Polyclonal catalytic antibodies | |
| dc.subject | Systemic lupus erythematosus | |
| dc.title | Mechanism of action of DNA-hydrolyzing antibodies to DNA from blood of patients with systemic lupus erythematosus | |
| dc.type | Article | |
| dc.relation.ispartofseries-issue | 11 | |
| dc.relation.ispartofseries-volume | 71 | |
| dc.collection | Публикации сотрудников КФУ | |
| dc.relation.startpage | 1238 | |
| dc.source.id | SCOPUS00062979-2006-71-11-SID33751511799 |
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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.