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Over-expression of Oct4 and Sox2 transcription factors enhances differentiation of human umbilical cord blood cells in vivo

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dc.contributor.author Guseva D.
dc.contributor.author Rizvanov A.
dc.contributor.author Salafutdinov I.
dc.contributor.author Kudryashova N.
dc.contributor.author Palotás A.
dc.contributor.author Islamov R.
dc.date.accessioned 2018-09-18T20:02:02Z
dc.date.available 2018-09-18T20:02:02Z
dc.date.issued 2014
dc.identifier.issn 0006-291X
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/135917
dc.description.abstract © 2014 Elsevier Inc. All rights reserved. Gene and cell-based therapies comprise innovative aspects of regenerative medicine. Even though stem cells represent a highly potential therapeutic strategy, their wide-spread exploitation is marred by ethical concerns, potential for malignant transformation and a plethora of other technical issues, largely restricting their use to experimental studies. Utilizing genetically modified human umbilical cord blood mono-nuclear cells (hUCB-MCs), this communication reports enhanced differentiation of transplants in a mouse model of amyotrophic lateral sclerosis (ALS). Over-expressing Oct4 and Sox2 induced production of neural marker PGP9.5, as well as transformation of hUCB-MCs into micro-glial and endothelial lines in ALS spinal cords. In addition to producing new nerve cells, providing degenerated areas with trophic factors and neo-vascularisation might prevent and even reverse progressive loss of moto-neurons and skeletal muscle paralysis.
dc.relation.ispartofseries Biochemical and Biophysical Research Communications
dc.subject Amyotrophic lateral sclerosis
dc.subject Differentiation
dc.subject Pluripotency
dc.subject Transcription factor
dc.subject Umbilical cord blood mono-nuclear cell
dc.title Over-expression of Oct4 and Sox2 transcription factors enhances differentiation of human umbilical cord blood cells in vivo
dc.type Article
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 451
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 503
dc.source.id SCOPUS0006291X-2014-451-4-SID84908367410


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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