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Surfactant media for constant-current coulometry. Application for the determination of antioxidants in pharmaceuticals

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dc.contributor.author Ziyatdinova G.
dc.contributor.author Ziganshina E.
dc.contributor.author Budnikov H.
dc.date.accessioned 2018-09-18T20:01:16Z
dc.date.available 2018-09-18T20:01:16Z
dc.date.issued 2012
dc.identifier.issn 0003-2670
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/135804
dc.description.abstract Effect of surfactant presence on electrochemical generation of titrants has been evaluated and discussed for the first time. Cationic (1-dodecylpyridinium and cetylpyridinium bromide), anionic (sodium dodecyl sulfate) and nonionic (Triton X100 and Brij® 35) surfactants as well as nonionic high molecular weight polymer (PEG 4000) do not react with the electrogenerated bromine, iodine and hexacyanoferrate(III) ions. The electrogenerated chlorine chemically interact with Triton X100 and Brij® 35. The allowable range of surfactants concentrations providing 100% current yield has been found. Chain-breaking low molecular weight antioxidants (ascorbic acid, rutin, α-tocopherol and retinol) were determined by reaction with the electrogenerated titrants in surfactant media. Nonionic and cationic surfactants can be used for the determination of antioxidants by reaction with the electrogenerated halogens. On contrary, cationic surfactants gives significantly overstated results of antioxidants determination with electrogenerated hexacyanoferrate(III) ions. The use of surfactants in coulometry of α-tocopherol and retinol provides their solubilization and allows to perform titration in water media. Simple, express and reliable coulometric approach for determination of α-tocopherol, rutin and ascorbic acid in pharmaceuticals using surfactant media has been developed. The relative standard deviation of the measurements does not exceed of 5%. © 2012 Elsevier B.V..
dc.relation.ispartofseries Analytica Chimica Acta
dc.subject Antioxidants
dc.subject Constant-current coulometry
dc.subject Electrogenerated oxidants
dc.subject Pharmaceutical analysis
dc.subject Surfactant media
dc.title Surfactant media for constant-current coulometry. Application for the determination of antioxidants in pharmaceuticals
dc.type Article
dc.relation.ispartofseries-volume 744
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 23
dc.source.id SCOPUS00032670-2012-744-SID84865545953


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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