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The influence of native ribonucleases and their modified derivatives on the functional activity of rat peritoneal macrophages

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dc.contributor.author Kalacheva N.
dc.contributor.author Kurinenko B.
dc.date.accessioned 2018-09-17T22:01:13Z
dc.date.available 2018-09-17T22:01:13Z
dc.date.issued 2005
dc.identifier.issn 2310-6905
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/135731
dc.description.abstract The influence of native, hydrophobized and dimeric forms of ribonucleases (RNAse A and RNAse Bacillus intermedius) on the process of phagocytosis and fusion between lysosomes and phagosomes in rat macrophages has been studied. The effect of native RNAses depends on their concentration: comparatively low concentrations (0.5-50 μg ml-1) stimulate the phagocytosis and phagosome-lysosome fusion whereas high concentrations (above 75 μg ml -1) inhibit these processes. RNAses modified by surfactant oxanol-KD-6 and dimeric forms of RNAses possess only the inhibitory effect, which appears at concentration considerably lower than that of native enzymes. The stimulatory effect of native RNAses and the inhibitory effect of hydrophobized derivatives do not depend on the catalytic activity.
dc.relation.ispartofseries Biomeditsinskaya Khimiya
dc.subject Inhibition
dc.subject Lysosome-phagosome fusion
dc.subject Macrophage
dc.subject RNAse
dc.title The influence of native ribonucleases and their modified derivatives on the functional activity of rat peritoneal macrophages
dc.type Article
dc.relation.ispartofseries-issue 3
dc.relation.ispartofseries-volume 51
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 303
dc.source.id SCOPUS23106905-2005-51-3-SID26944433464


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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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