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Role of cGMP- and cAMP-dependent systems in the effects of nitric oxide on transmitter release and potassium currents in the frog neuromuscular junction

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dc.contributor.author Yakovlev A.
dc.contributor.author Sitdikova G.
dc.contributor.author Zefirov A.
dc.date.accessioned 2018-09-17T21:36:40Z
dc.date.available 2018-09-17T21:36:40Z
dc.date.issued 2002
dc.identifier.issn 0090-2977
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/135208
dc.description.abstract We studied the molecular mechanisms responsible for nitric oxide (NO)-evoked modulation of the synaptic function in the frog neuromuscular junction using inhibitors of adenylate and guanylate cyclases and analogs of cyclic nucleotides. It was shown that application of an exogenous donor of NO, sodium nitroprusside, decreased transmitter release and increased the amplitude of voltage-dependent potassium current of the nerve endings. Our results indicate that NO regulates transmitter release and potassium current in the frog neuromuscular junction both via cAMP- and cGMP-dependent mechanisms.
dc.relation.ispartofseries Neurophysiology
dc.subject Adenylate cyclase
dc.subject cAMP
dc.subject cGMP
dc.subject Guanylate cyclase
dc.subject Neuromuscular transmission
dc.subject Nitric oxide
dc.title Role of cGMP- and cAMP-dependent systems in the effects of nitric oxide on transmitter release and potassium currents in the frog neuromuscular junction
dc.type Conference Paper
dc.relation.ispartofseries-issue 2-3
dc.relation.ispartofseries-volume 34
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 258
dc.source.id SCOPUS00902977-2002-34-23-SID0036524220


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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