Genotoxic Effects of Metabolic Derivatives of the New Drug Phosphabenzide

dc.contributor.author	Il'inskaya O.
dc.contributor.author	Ivanchenko O.
dc.contributor.author	Trubnikova G.
dc.contributor.author	Valimukhametova D.
dc.contributor.author	Tarasova R.
dc.contributor.author	Bagautdinova D.
dc.date.accessioned	2018-09-17T21:00:54Z
dc.date.available	2018-09-17T21:00:54Z
dc.date.issued	1998
dc.identifier.issn	1022-7954
dc.identifier.uri	https://dspace.kpfu.ru/xmlui/handle/net/134397
dc.description.abstract	Genotoxic action of four possible metabolites of the new tranquilizer phosphabenzide (acetylphosphabenzide, diphenylphosphinylacetic acid, phosphabenzide hydrazone with pyruvic acid, bis-1,2-(diphenylphosphinylacetyl)hydrazine has been studied. These metabolites belong to slightly toxic phosphororganic compounds. The Ames Salmonella/microsomes tests performed on strains TA100 and TA98 showed that of these compounds only acetylphosphabenzide possessed mutagenic action. Metabolic activation of liver microsomes decreased the mutagenic effect. The mechanism of action of acetylphosphabenzide is likely to involve the formation of acetylhydrazine, capable of producing active electrophiles attacking DNA.
dc.relation.ispartofseries	Russian Journal of Genetics
dc.title	Genotoxic Effects of Metabolic Derivatives of the New Drug Phosphabenzide
dc.type	Article
dc.relation.ispartofseries-issue	2
dc.relation.ispartofseries-volume	34
dc.collection	Публикации сотрудников КФУ
dc.relation.startpage	236
dc.source.id	SCOPUS10227954-1998-34-2-SID1842813247

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