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1,3-Disubstituted p-tert-butylcalix[4]arenes as cholinesterase inhibitors

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dc.contributor.author Stoikova E.
dc.contributor.author Evtugyn G.
dc.contributor.author Belyakova S.
dc.contributor.author Khrustalev A.
dc.contributor.author Stoikov I.
dc.contributor.author Antipin I.
dc.contributor.author Budnikov H.
dc.contributor.author Konovalov A.
dc.date.accessioned 2018-09-17T20:51:55Z
dc.date.available 2018-09-17T20:51:55Z
dc.date.issued 2001
dc.identifier.issn 0923-0750
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/134173
dc.description.abstract The inhibitory effect of 1,3-substituted p-tert-butylcalix[4]arenes on butyrylcholinesterase from horse serum has been discovered and kinetically investigated with photometric microassay techniques. The interaction of calix[4]arene with the enzyme is described in accordance with the formal kinetics of competitive reversible inhibition. The inhibition constants calculated depend on the substituent in the lower rim of the calix[4]arene and vary in the range of (5-110) × 10-6 M. The proposed mechanism of inhibition involves the cooperative interaction of indophenyl acetate used as a substrate, calix[4]arene and the enzyme without any covalent or electrostatic binding of the functional groups in the active site of cholinesterase. This results in the coordination of the calixarene on the enzyme surface in the proximity of the enzyme active site. Such interaction prevents the substrate from entering the enzyme active site.
dc.relation.ispartofseries Journal of Inclusion Phenomena
dc.subject Calix[4]arene
dc.subject Cholinesterase
dc.subject Ester binding
dc.subject Inhibition
dc.title 1,3-Disubstituted p-tert-butylcalix[4]arenes as cholinesterase inhibitors
dc.type Article
dc.relation.ispartofseries-issue 3-4
dc.relation.ispartofseries-volume 39
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 339
dc.source.id SCOPUS09230750-2001-39-34-SID0346507907


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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