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Atomic force microscope for investigation of DNA-hydrolyzing activity of anti-DNA antibodies
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| dc.contributor.author | Vinter V. | |
| dc.contributor.author | Nevzorova T. | |
| dc.contributor.author | Konovalova O. | |
| dc.contributor.author | Salakhov M. | |
| dc.date.accessioned | 2018-09-17T20:48:56Z | |
| dc.date.available | 2018-09-17T20:48:56Z | |
| dc.date.issued | 2005 | |
| dc.identifier.issn | 0869-5652 | |
| dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/134097 | |
| dc.description.abstract | Interaction of DNA-hydrolyzing antibodies and DNA with super-twisted plasmid DNA pBR-322 was studied at one of wide spread human autoimmune disease of unknown etiology - exanthematous systemic lupus. It is shown that investigated antibodies and DNA are endonucleases and make one-thread breaks in super-twisted DNA molecules, transforming them into the ring molecules. Using atomic force microscopy, formation of stable immune complex antibody-DNA was registered, the complex size exceeding individual sizes of antibodies and DNA molecule. Probably, abzymes interact with DNA initially with the mechanisms characteristic for antigen-antibody immune complex formation, and further the antibody fermentative properties manifest. However, unlike ordinary DNAses, after phosphodiester bond hydrolysis the antibody molecule is not disengaged from DNA molecule. | |
| dc.relation.ispartofseries | Doklady Akademii Nauk | |
| dc.title | Atomic force microscope for investigation of DNA-hydrolyzing activity of anti-DNA antibodies | |
| dc.type | Article | |
| dc.relation.ispartofseries-issue | 3 | |
| dc.relation.ispartofseries-volume | 405 | |
| dc.collection | Публикации сотрудников КФУ | |
| dc.relation.startpage | 409 | |
| dc.source.id | SCOPUS08695652-2005-405-3-SID33644629786 |
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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.