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Models of 2,4,6-trinitrotoluene (TNT) initial conversion by yeasts

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dc.contributor.author Zaripov S.
dc.contributor.author Naumov A.
dc.contributor.author Abdrakhmanova J.
dc.contributor.author Garusov A.
dc.contributor.author Naumova R.
dc.date.accessioned 2018-09-17T20:43:13Z
dc.date.available 2018-09-17T20:43:13Z
dc.date.issued 2002
dc.identifier.issn 0378-1097
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/133938
dc.description.abstract The original models of the initial steps of 2,4,6-trinitrotoluene (TNT) conversion by yeasts are presented. Saccharomyces sp. ZS-A1 reduced nitro groups of TNT producing isomeric monohydroxylaminodinitrotoluenes (HADNT) as the key initial metabolites (molar ratio HADNT/TNT was up to 0.81), whereas aminodinitrotoluenes (ADNT) and the hydride-Meisenheimer complex of TNT (H-TNT) were the minor products. Conversely, Candida sp. AN-L13 transformed TNT almost quantitatively into H-TNT, thus realizing the alternative attack, consisting of the TNT aromatic ring reduction. The third type of conversion, revealed in Candida sp. AN-L14, is the combination of both above mechanisms and produces an equimolar mix of HADNT and H-TNT. In the toxicity tests with Paramecium caudatum, the supernatant of Saccharomyces sp. ZS-A1, which converts TNT into HADNT, was most toxic while the supernatant of Candida sp. AN-L13 (TNT→H-TNT) was least toxic. The microorganisms converting TNT quantitatively to the reactive metabolites can be useful for their immobilization through the detoxifying interaction with the soil components such as humic compounds. © 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
dc.relation.ispartofseries FEMS Microbiology Letters
dc.subject 2,4,6-Trinitrotoluene
dc.subject Explosives and oil contamination
dc.subject Initial transformation
dc.subject Reactive metabolite
dc.subject Toxicity
dc.subject Yeast
dc.title Models of 2,4,6-trinitrotoluene (TNT) initial conversion by yeasts
dc.type Article
dc.relation.ispartofseries-issue 2
dc.relation.ispartofseries-volume 217
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 213
dc.source.id SCOPUS03781097-2002-217-2-SID0037126663


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  • Публикации сотрудников КФУ Scopus [20180]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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