dc.contributor.author |
Nevzorova T. |
|
dc.contributor.author |
Temnikov D. |
|
dc.contributor.author |
Vinter V. |
|
dc.date.accessioned |
2018-09-17T20:41:07Z |
|
dc.date.available |
2018-09-17T20:41:07Z |
|
dc.date.issued |
2003 |
|
dc.identifier.issn |
0320-9725 |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/133879 |
|
dc.description.abstract |
Two types of IgG anti-DNA antibodies exhibiting DNA-hydrolyzing activity have been isolated from blood serum of patients with systemic lupus erythematosus. This DNase activity of antibodies differs from serum DNases by the non-processive mode, temperature resistance, pH optimum, and the rate of DNA hydrolysis. It is suggested that the anti-DNA antibody molecule possessing DNase activity contains two sites: one site determines specificity of antibody-DNA interaction, whereas the other is responsible for manifestation of the catalytic activity. |
|
dc.relation.ispartofseries |
Biokhimiya |
|
dc.subject |
Abzymes |
|
dc.subject |
DNA hydrolysis |
|
dc.subject |
IgG |
|
dc.subject |
Polyclonal catalytic antibodies |
|
dc.subject |
Systemic lupus erythematosus |
|
dc.title |
Special features of the DNA-hydrolyzing activity of the antibodies in systemic lupus erythematosus |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
12 |
|
dc.relation.ispartofseries-volume |
68 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
1616 |
|
dc.source.id |
SCOPUS03209725-2003-68-12-SID1542638016 |
|