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dc.contributor.author | Nevzorova T. | |
dc.contributor.author | Temnikov D. | |
dc.contributor.author | Vinter V. | |
dc.date.accessioned | 2018-09-17T20:41:07Z | |
dc.date.available | 2018-09-17T20:41:07Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 0320-9725 | |
dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/133879 | |
dc.description.abstract | Two types of IgG anti-DNA antibodies exhibiting DNA-hydrolyzing activity have been isolated from blood serum of patients with systemic lupus erythematosus. This DNase activity of antibodies differs from serum DNases by the non-processive mode, temperature resistance, pH optimum, and the rate of DNA hydrolysis. It is suggested that the anti-DNA antibody molecule possessing DNase activity contains two sites: one site determines specificity of antibody-DNA interaction, whereas the other is responsible for manifestation of the catalytic activity. | |
dc.relation.ispartofseries | Biokhimiya | |
dc.subject | Abzymes | |
dc.subject | DNA hydrolysis | |
dc.subject | IgG | |
dc.subject | Polyclonal catalytic antibodies | |
dc.subject | Systemic lupus erythematosus | |
dc.title | Special features of the DNA-hydrolyzing activity of the antibodies in systemic lupus erythematosus | |
dc.type | Article | |
dc.relation.ispartofseries-issue | 12 | |
dc.relation.ispartofseries-volume | 68 | |
dc.collection | Публикации сотрудников КФУ | |
dc.relation.startpage | 1616 | |
dc.source.id | SCOPUS03209725-2003-68-12-SID1542638016 |