Kazan Federal University Digital Repository

Effect of chain length on interactions of aliphatic alcohols with suspended human serum albumin

Show simple item record

dc.contributor.author Sirotkin V.
dc.contributor.author Borisover M.
dc.contributor.author Solomonov B.
dc.date.accessioned 2018-09-17T20:38:56Z
dc.date.available 2018-09-17T20:38:56Z
dc.date.issued 1997
dc.identifier.issn 0301-4622
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/133822
dc.description.abstract Enthalpy changes on the immersion of human serum albumin (HSA) into n-butanol, n-propanol, ethanol and methanol containing different amounts of water have been measured calorimetrically at 25°C. Water sorption isotherms on HSA were also determined in water-n-butanol and water-ethanol mixtures. From comparison of the calorimetric and sorption data, it was concluded that there is a significant enthalpy change on the HSA immersion into methanol and ethanol even under conditions where there is no change in the quantity of adsorbed water. No similar contribution was found in the n-butanol based suspensions. Water monolayer capacity evaluated from the Langmuir model decreases also significantly when going from ethanol to n-butanol. Considering this non water sorption contribution, values of the monolayer capacity and the shape of the experimental dependences, it was inferred that a relatively small change of the solvent molecule structure (from n-propanol to ethanol) affects strongly the interactions of the protein with the solvent.
dc.relation.ispartofseries Biophysical Chemistry
dc.subject Aliphatic alcohols
dc.subject Enthalpy of immersion
dc.subject Human serum albumin
dc.subject Interactions
dc.subject Langmuir model
dc.subject Water sorption
dc.title Effect of chain length on interactions of aliphatic alcohols with suspended human serum albumin
dc.type Article
dc.relation.ispartofseries-issue 2-3
dc.relation.ispartofseries-volume 69
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 239
dc.source.id SCOPUS03014622-1997-69-23-SID0031468585


Files in this item

This item appears in the following Collection(s)

  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics