dc.contributor.author |
Ilinskaya O. |
|
dc.contributor.author |
Decker K. |
|
dc.contributor.author |
Koschinski A. |
|
dc.contributor.author |
Dreyer F. |
|
dc.contributor.author |
Repp H. |
|
dc.date.accessioned |
2018-09-17T20:38:50Z |
|
dc.date.available |
2018-09-17T20:38:50Z |
|
dc.date.issued |
2001 |
|
dc.identifier.issn |
0300-483X |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/133819 |
|
dc.description.abstract |
The antiproliferative action of the guanine-specific ribonuclease secreted by Bacillus intermedius (binase) was studied in different chicken and mouse cell lines. The proliferation rate of chicken embryo fibroblasts, either normal or Rous sarcoma virus-transformed, was significantly reduced by binase treatment. Among mouse fibroblasts, v-ras-transformed NIH3T3 cells were sensitive to binase, whereas the growth of non-transformed, v-src-transformed or v-fms-transformed NIH3T3 cells was not affected. A 48 h treatment with binase inhibited the Ca2+-dependent K+ current of v-ras-transformed NIH3T3 cells but had no effect on this membrane current in non-transformed and in v-src- or v-fms-transformed NIH3T3 cells. Our results suggest that mammalian cells expressing the ras-oncogene are a potential target for the antiproliferative action of binase. © 2001 Elsevier Science Ireland Ltd. |
|
dc.relation.ispartofseries |
Toxicology |
|
dc.subject |
Bacillus intermedius RNase (binase) |
|
dc.subject |
Ca2+-dependent K+ current |
|
dc.subject |
Chicken embryo fibroblasts |
|
dc.subject |
Mouse fibroblasts |
|
dc.subject |
Proliferation |
|
dc.subject |
Transformation |
|
dc.title |
Bacillus intermedius ribonuclease as inhibitor of cell proliferation and membrane current |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
2-3 |
|
dc.relation.ispartofseries-volume |
156 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
101 |
|
dc.source.id |
SCOPUS0300483X-2001-156-23-SID0035793124 |
|