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Characteristics of interpolyelectrolyte complexes of Eudragit E100 with Eudragit L100

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dc.contributor.author Moustafine R.
dc.contributor.author Kabanova T.
dc.contributor.author Kemenova V.
dc.contributor.author Van Den Mooter G.
dc.date.accessioned 2018-09-17T20:31:52Z
dc.date.available 2018-09-17T20:31:52Z
dc.date.issued 2005
dc.identifier.issn 0168-3659
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/133623
dc.description.abstract With a view to the application in oral controlled drug delivery systems, the formation of interpolyelectrolyte complexes (IPEC) between Eudragit E100 (EE) and Eudragit L100 (EL) was investigated, using turbidimetry, solution viscosity measurements and elementary analysis. The structure of the synthesized IPEC was investigated by using FT-IR spectroscopy. The binding ratio of a unit molecule of EL with EE was found to be approximately 1:1 in pH 6.0. Based on the results of elementary analysis, and FT-IR, the binding ratio of each component in the solid complexes was very close to that observed in turbidity and viscosity measurements and indicate that the synthesized products can be considered as IPEC. Due to the structure of the IPEC, two maxima were observed in the swelling behaviour as a function of pH. The release of the model drug ibuprofen was significantly retarded from tablets made up of the IPEC. © 2004 Elsevier B.V. All rights reserved.
dc.relation.ispartofseries Journal of Controlled Release
dc.subject Controlled release
dc.subject Eudragit E100
dc.subject Eudragit L100
dc.subject Ibuprofen
dc.subject Interpolyelectrolyte complex
dc.title Characteristics of interpolyelectrolyte complexes of Eudragit E100 with Eudragit L100
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 103
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 191
dc.source.id SCOPUS01683659-2005-103-1-SID13844250268

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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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