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Alternative pathways of the initial transformation of 2,4,6-trinitrotoluene by yeasts

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dc.contributor.author Zaripov S.
dc.contributor.author Naumov A.
dc.contributor.author Nikitina E.
dc.contributor.author Naumova R.
dc.date.accessioned 2018-09-17T20:31:01Z
dc.date.available 2018-09-17T20:31:01Z
dc.date.issued 2002
dc.identifier.issn 0026-2617
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/133601
dc.description.abstract A new model for the initial transformation of 2,4,6-trinitrotoluene (TNT) by facultatively anaerobic and aerobic yeasts is presented. The model is based on the data that Saccharomyces sp. ZS-Al was able to reduce the nitrogroups of TNT with the formation of 2- and 4-hydroxyaminodinitrotoluenes (2-HADNT and 4-HADNT) as the major early TNT metabolites (the molar HADNT/TNT ratio reached 0.81), whereas aminodinitrotoluenes (ADNTs) and the hydride-Meisenheimer complex of TNT (H-TNT) were the minor products. Candida sp. AN-L13 almost completely transformed TNT into H-TNT through the reduction of the aromatic ring. Candida sp. AN-L14 transformed TNT through a combination of the two mechanisms described. Aeration stimulated the production of HADNT from TNT, whereas yeast incubation under stationary conditions promoted the formation of HADNT. The transformation of TNT into HADNT led to a tenfold increase in the acute toxicity of the TNT preparation with respect to Paramecium caudatum, whereas the increase in the toxicity was about twofold in the case of the alternative attack at the aromatic ring. © 2002 MAIK "Nauka/Interperiodica".
dc.relation.ispartofseries Microbiology
dc.subject 2,4,6-trinitrotoluene
dc.subject Initial transformation
dc.subject Toxicity
dc.subject Yeasts
dc.title Alternative pathways of the initial transformation of 2,4,6-trinitrotoluene by yeasts
dc.type Article
dc.relation.ispartofseries-issue 5
dc.relation.ispartofseries-volume 71
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 558
dc.source.id SCOPUS00262617-2002-71-5-SID27144559788


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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