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dc.contributor.author | Karamova N. | |
dc.contributor.author | Mynina I. | |
dc.contributor.author | Garaeva G. | |
dc.contributor.author | Ivanchenko O. | |
dc.contributor.author | Ilinskaya O. | |
dc.date.accessioned | 2018-09-17T20:13:28Z | |
dc.date.available | 2018-09-17T20:13:28Z | |
dc.date.issued | 1995 | |
dc.identifier.issn | 0016-6758 | |
dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/133203 | |
dc.description.abstract | The genotoxicity of 2,4,6-trinitrotoluene (2,4,6-TNT) and its amino derivative, 2,4-diamino-6-nitrotoluene (2,4-DA-6-NT), was studied using the Escherichia coli tester strain PQ37 in the SOS chromotest. The compound 2,4,6-TNT, without metabolic activation, virtually failed to induce an SOS effect in cells of the tester bacteria. Consequently, mutagenic activity of 2,4,6-TNT, which was shown earlier in the Ames test, does not depend on SOS mutagenesis. It was demonstrated that metabolic activation with the microsomal S9 human placenta fraction results in a threefold increase in the induction factor of the SOS effect caused by 2,4,6-TNT. The absence of the SOS-inducing activity of 2,4-DA-6-NT, regardless of the presence of a microsomal activating mixture, is shown. Thus, 2,4-DA-6-NT does not belong to metabolites of 2,4,6-TNT, responsible for the genotoxicity of this compound. | |
dc.relation.ispartofseries | Genetika | |
dc.title | Compounds 2,4,6-trinitrotoluene and 2,4-diamino-6-nitrotoluene: The absence of recA-dependent mutagenesis? | |
dc.type | Article | |
dc.relation.ispartofseries-issue | 5 | |
dc.relation.ispartofseries-volume | 31 | |
dc.collection | Публикации сотрудников КФУ | |
dc.relation.startpage | 617 | |
dc.source.id | SCOPUS00166758-1995-31-5-SID0029079735 |