Blockade of hyperpolarization-activated channels modifies the effect of β-adrenoceptor stimulation

dc.contributor.author	Zefirov T.
dc.contributor.author	Ziyatdinova N.
dc.contributor.author	Gainullin A.
dc.contributor.author	Zefirov A.
dc.date.accessioned	2018-09-17T20:10:44Z
dc.date.available	2018-09-17T20:10:44Z
dc.date.issued	2002
dc.identifier.issn	0007-4888
dc.identifier.uri	https://dspace.kpfu.ru/xmlui/handle/net/133143
dc.description.abstract	Experiments on rats showed that blockade of hyperpolarization-activated currents moderates tachycardia induced by β-adrenoceptor agonist isoproterenol and potentiates the increase in stroke volume produced by this agonist. Electrical stimulation of the vagus nerve against the background of isoproterenol treatment augmented bradycardia and increased stroke volume. Blockade of hyperpolarization-activated currents followed by application of isoproterenol moderated vagus-induced bradycardia and had no effect on the dynamics of stroke volume.
dc.relation.ispartofseries	Bulletin of Experimental Biology and Medicine
dc.subject	Heart
dc.subject	Hyperpolarization currents
dc.subject	Rat
dc.subject	Sympathetic influences
dc.subject	Vagus
dc.title	Blockade of hyperpolarization-activated channels modifies the effect of β-adrenoceptor stimulation
dc.type	Article
dc.relation.ispartofseries-issue	5
dc.relation.ispartofseries-volume	133
dc.collection	Публикации сотрудников КФУ
dc.relation.startpage	425
dc.source.id	SCOPUS00074888-2002-133-5-SID0036558735

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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.