Dependence of the concentration of half-maximal effect of an open-channel blocker on the agonist concentration

dc.contributor.author	Skorinkin A.
dc.contributor.author	Maleev N.
dc.contributor.author	Shaikhutdinova A.
dc.date.accessioned	2018-09-17T20:10:03Z
dc.date.available	2018-09-17T20:10:03Z
dc.date.issued	2005
dc.identifier.issn	0006-3509
dc.identifier.uri	https://dspace.kpfu.ru/xmlui/handle/net/133127
dc.description.abstract	The dependence of the amplitudes of steady-state current responses on the blocker concentration was described by analyzing a kinetic scheme for the blockage of open channels at an arbitrary number of blocker-binding sites. Also described is a variant of this dependence for the case when the blocker can be retained in a channel after its closing. It was shown that the applicability of the Hill equation is limited and it is necessary to take into account the dependence of the concentration of half-maximal effect of the blocker on the agonist concentration. Copyright © 2005 by MAIK "Nauka/ Interperiodica".
dc.relation.ispartofseries	Biophysics
dc.subject	Kinetic modeling
dc.subject	Postsynaptic receptor
dc.subject	Steady-state conditions
dc.title	Dependence of the concentration of half-maximal effect of an open-channel blocker on the agonist concentration
dc.type	Article
dc.relation.ispartofseries-issue	2
dc.relation.ispartofseries-volume	50
dc.collection	Публикации сотрудников КФУ
dc.relation.startpage	269
dc.source.id	SCOPUS00063509-2005-50-2-SID33750570459

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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.