Special Features of the DNA-Hydrolyzing Activity of the Antibodies in Systemic Lupus Erythematosus

dc.contributor.author	Nevzorova T.
dc.contributor.author	Temnikov D.
dc.contributor.author	Vinter V.
dc.date.accessioned	2018-09-17T20:09:08Z
dc.date.available	2018-09-17T20:09:08Z
dc.date.issued	2003
dc.identifier.issn	0006-2979
dc.identifier.uri	https://dspace.kpfu.ru/xmlui/handle/net/133105
dc.description.abstract	Two types of IgG anti-DNA antibodies exhibiting DNA-hydrolyzing activity have been isolated from blood serum of patients with systemic lupus erythematosus. This DNase activity of antibodies differs from serum DNases by the non-processive mode, temperature resistance, pH optimum, and the rate of DNA hydrolysis. It is suggested that the anti-DNA anti-body molecule possessing DNase activity contains two sites: one site determines specificity of antibody-DNA interaction, whereas the other is responsible for manifestation of the catalytic activity.
dc.relation.ispartofseries	Biochemistry (Moscow)
dc.subject	Abzymes
dc.subject	DNA hydrolysis
dc.subject	IgG
dc.subject	Polyclonal catalytic antibodies
dc.subject	Systemic lupus erythematosus
dc.title	Special Features of the DNA-Hydrolyzing Activity of the Antibodies in Systemic Lupus Erythematosus
dc.type	Article
dc.relation.ispartofseries-issue	12
dc.relation.ispartofseries-volume	68
dc.collection	Публикации сотрудников КФУ
dc.relation.startpage	1300
dc.source.id	SCOPUS00062979-2003-68-12-SID0742285862

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Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.