Synthesis of 5-methyl-2-ethyl-4-chloro-2-oxo-1,2-oxa-4-hospholene

Abstract

1. The counter synthesis of 5-methyl-2-ethyl-4-chloro-2-oxo-l,2-oxa-4-phospholene was accomplished. 2. The 4-methyl-2-ethyl- and 4-methyl-2-phenyl-5-methylene-2-oxo-1,2-oxa-3-phospholenes were obtained by the chlorination and dehydrochlorination of the 4,5-dimethy1-2-ethyl- and 4,5-dimethy1-2-pheny1-2-oxo-1,2-oxa-4-phospholenes. 3. The 4-methyl-2-ethyl (or phenyl)-5-methylene-2-oxo-1,2-oxa-3-phospolenes when treated with water or alcohols are converted to the corresponding phosphorylated α, β-unsaturated ketones. © 1971 Consultants Bureau.