The Effect of l-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidin-2-One on the Regeneration of the Planarian Girardia tigrina

Abstract

© 2017, Springer Science+Business Media, LLC. The effect of l-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one, a co-crystal of Xymedon with ascorbic acid, derived from pyrimidine on the regeneration process of the planarian Girardia tigrina (Girard, 1850) has been investigated. Being a co-crystal of Xymedon with ascorbic acid, the preparation is characterized by the improved properties compared to Xymedon. The new preparation falls within the group of hepatoprotectors capable of liver regeneration in response to various destructive factors. It has been shown that the new preparation at different concentration levels can inhibit planarian head regeneration. Two combinations of the test substance were used in the work: a neat form of the preparation; a mixture of the preparation with Na2CO3 to reduce the acidity of the test substance. The neat preparation showed a statistically insignificant tendency to an increase in the regeneration of G. tigrina planarians. When mixed with Na2CO3, the preparation inhibited the regeneration of G. tigrina planarians. G. tigrina planarians is a popular model for studying regeneration processes and stem cell proliferation.