Regulatory Profile Changes of Lymphocytes and Peripheral Blood Monocytes in Children with Candidiasis Associated with Chronic Somatic Diseases

Abstract

© 2017, Springer Science+Business Media, LLC. In this paper, we report results of the study of immune parameters with the assessment of regulatory and effector subpopulations of lymphocytes and monocytes with candidiasis in children with chronic somatic diseases (secondary pyelonephritis and obstructive diseases of the upper gastrointestinal tract). Candidiasis was diagnosed by the rising level of circulating Candida albicans mannan antigen and culture mycological research. It was found that the persistence of fungi is associated with differentiated regulatory changes in the structure of subpopulations of lymphocytes and monocytes with preferential increase of immunosuppressive cells (CD4+CD25+hi, CD3+CD16/56+, CD3−CD8+, CD3+4 amid reduction of effector subpopulations of lymphocytes and antigen presenting cells associated with Th1 immune response profile.