dc.contributor.author |
Brütting C. |
|
dc.contributor.author |
Kataeva O. |
|
dc.contributor.author |
Schmidt A. |
|
dc.contributor.author |
Knölker H. |
|
dc.date.accessioned |
2018-04-05T07:09:51Z |
|
dc.date.available |
2018-04-05T07:09:51Z |
|
dc.date.issued |
2017 |
|
dc.identifier.issn |
1434-193X |
|
dc.identifier.uri |
http://dspace.kpfu.ru/xmlui/handle/net/130014 |
|
dc.description.abstract |
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim We describe the first total synthesis of the cytotoxic carbazole alkaloid excavatine-A. The carbazole framework was constructed through double C–H bond activation of a diarylamine by using our palladium(II)-catalyzed oxidative cyclization. Treatment of the intermediate 8-hydroxycarbazoles with prenal and different additives led either to pyrano[2,3-a]carbazoles or to [1,4] oxazepino[2,3,4-jk]carbazoles. The pyran annulation was investigated to determine the influence of substitution pattern, additives, and reaction time on the selectivity. |
|
dc.relation.ispartofseries |
European Journal of Organic Chemistry |
|
dc.subject |
Alkaloids |
|
dc.subject |
Carbazoles |
|
dc.subject |
Oxazepines |
|
dc.subject |
Palladium |
|
dc.subject |
Total synthesis |
|
dc.title |
First Total Synthesis of the Cytotoxic Carbazole Alkaloid Excavatine-A and Regioselective Annulation to Pyrano[2,3-a]carbazoles and [1,4]Oxazepino[2,3,4-jk]carbazoles |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
22 |
|
dc.relation.ispartofseries-volume |
2017 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
3288 |
|
dc.source.id |
SCOPUS1434193X-2017-2017-22-SID85020530327 |
|