Nanoscale hydrophilic colloids with high relaxivity and low cytotoxicity based on Gd(III) complexes with Keplerate polyanions

Abstract

© The Royal Society of Chemistry and the Centre National de la Recherche Scientifique. The work introduces for the first time Mo-132-type Keplerates (Kp) and Gd 3+ ions as a basis for the one-pot synthesis of aqueous colloids with high longitudinal relaxivity (r 1 = 96.4 mM -1 s -1 at 20 MHz). The hydrophilic coating of small (3-5 nm) Gd x (Kp) y -based cores provides their colloid stabilization, protection from degradation and low cytotoxicity.