Электронный архив

Potential role of IL-37 in atherosclerosis

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dc.contributor.author McCurdy S.
dc.contributor.author Liu C.
dc.contributor.author Yap J.
dc.contributor.author Boisvert W.
dc.date.accessioned 2018-04-05T07:09:30Z
dc.date.available 2018-04-05T07:09:30Z
dc.date.issued 2017
dc.identifier.issn 1043-4666
dc.identifier.uri http://dspace.kpfu.ru/xmlui/handle/net/129778
dc.description.abstract © 2017 Elsevier Ltd. IL-37 is a member of the IL-1 family, but unlike most other members of this family of cytokines, it has wide-ranging anti-inflammatory properties. Initially shown to bind IL-18 binding protein and prevent IL-18-mediated inflammation, its known role has been expanded to include distinct pathways, both intracellular involving the transcription factor Smad3, and extracellular via binding to the orphan receptor IL-1R8. A number of recent publications investigating the role of IL-37 in atherosclerosis and ischemic heart disease have revealed promising therapeutic value of the cytokine. Although research concerning the role of IL-37 and its mechanism in atherosclerosis is relatively scant, there are a number of well-known atherosclerotic processes that this cytokine can mediate with the potential of modulating the disease progression itself. This review will probe in detail the effects of IL-37 on important pathological processes such as inflammation, dysregulated lipid metabolism, and apoptosis, by analyzing existing data as well as exploring the potential of this cytokine to influence these properties.
dc.relation.ispartofseries Cytokine
dc.subject Anti-inflammatory properties
dc.subject Atherosclerosis
dc.subject IL-37
dc.title Potential role of IL-37 in atherosclerosis
dc.type Article in Press
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS10434666-2017-SID85030552867


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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