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Hemocoagulation Activity of Sulfur-Containing Pinane-Type Terpenoids
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| dc.contributor.author | Kiselev S. | |
| dc.contributor.author | Nikitina L. | |
| dc.contributor.author | Startseva V. | |
| dc.contributor.author | Artemova N. | |
| dc.contributor.author | Bodrov A. | |
| dc.contributor.author | Boichuk S. | |
| dc.contributor.author | Vorontsova M. | |
| dc.contributor.author | Rakhmatullina A. | |
| dc.contributor.author | Turaev R. | |
| dc.contributor.author | Klochkov V. | |
| dc.date.accessioned | 2018-04-05T07:09:13Z | |
| dc.date.available | 2018-04-05T07:09:13Z | |
| dc.date.issued | 2017 | |
| dc.identifier.issn | 0091-150X | |
| dc.identifier.uri | http://dspace.kpfu.ru/xmlui/handle/net/129584 | |
| dc.description.abstract | © 2017, Springer Science+Business Media, LLC. A series of pinane-type sulfides and sulfoxides were synthesized from (1S)-(–)-β-pinene. Their hemocoagulation activity in vitro on human blood plasma was studied. All tested compounds exhibited antiaggregation and anticoagulation activity. The most water-soluble sulfoxide with a mercaptoacetic acid moiety inhibited spontaneous platelet aggregation and that induced by collagen and arachidonic acid and also reduced the coagulation activity of human blood plasma. The hemocoagulation activity was due to selective inhibition of platelet receptors, decreased yield of thrombocytic microvesicles, and suppression of their activity. | |
| dc.relation.ispartofseries | Pharmaceutical Chemistry Journal | |
| dc.subject | (1S)-(–)-β-pinene | |
| dc.subject | antiaggregation and anticoagulation activity | |
| dc.subject | platelets | |
| dc.subject | sulfides and sulfoxides | |
| dc.title | Hemocoagulation Activity of Sulfur-Containing Pinane-Type Terpenoids | |
| dc.type | Article | |
| dc.relation.ispartofseries-issue | 5 | |
| dc.relation.ispartofseries-volume | 51 | |
| dc.collection | Публикации сотрудников КФУ | |
| dc.relation.startpage | 343 | |
| dc.source.id | SCOPUS0091150X-2017-51-5-SID85029155775 |
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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.