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Analysis of Immunogenicity of Intracellular CTAR Fragments of Epstein—Barr Virus Latent Phase Protein LMP1
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| dc.contributor.author | Lomakin Y. | |
| dc.contributor.author | Shmidt A. | |
| dc.contributor.author | Bobik T. | |
| dc.contributor.author | Chernov A. | |
| dc.contributor.author | Pyrkov A. | |
| dc.contributor.author | Aleksandrova N. | |
| dc.contributor.author | Okunola D. | |
| dc.contributor.author | Vaskina M. | |
| dc.contributor.author | Ponomarenko N. | |
| dc.contributor.author | Telegin G. | |
| dc.contributor.author | Dubina M. | |
| dc.contributor.author | Belogurov A. | |
| dc.date.accessioned | 2018-04-05T07:08:52Z | |
| dc.date.available | 2018-04-05T07:08:52Z | |
| dc.date.issued | 2017 | |
| dc.identifier.issn | 0007-4888 | |
| dc.identifier.uri | http://dspace.kpfu.ru/xmlui/handle/net/129381 | |
| dc.description.abstract | © 2017, Springer Science+Business Media, LLC. Intracellular fragments of latent phase protein LMP1 of Epstein—Barr virus, denoted as CTAR1/2/3, can trigger a variety of cell cascades and contribute to the transforming potential of the virus. Generation of recombinant proteins CTAR1/2/3 is expected to yield more ample data on functional and immunogenic characteristics of LMP1. We created genetic constructs for prokaryotic expression of LMP1 CTAR fragments and selected optimal conditions for their production and purification. Using a new library of LMP1 CTAR fragments, we carried out epitope mapping of a diagnostic anti-LMP1 antibody S12. Analysis of polyclonal serum antibodies from mice immunized with full-length LMP1 confirmed immunogenicity of CTAR elements comparable with that of full-length protein. | |
| dc.relation.ispartofseries | Bulletin of Experimental Biology and Medicine | |
| dc.subject | epitope detection | |
| dc.subject | latent membrane protein 1 (LMP1) | |
| dc.subject | prokaryotic expression | |
| dc.subject | S12 monoclonal antibody | |
| dc.title | Analysis of Immunogenicity of Intracellular CTAR Fragments of Epstein—Barr Virus Latent Phase Protein LMP1 | |
| dc.type | Article | |
| dc.relation.ispartofseries-issue | 6 | |
| dc.relation.ispartofseries-volume | 163 | |
| dc.collection | Публикации сотрудников КФУ | |
| dc.relation.startpage | 766 | |
| dc.source.id | SCOPUS00074888-2017-163-6-SID85031932383 |
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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.