Application of Tetrameric Recombinant Human Butyrylcholinesterase as a Biopharmaceutical for Amelioration of Symptoms of Acute Organophosphate Poisoning

dc.contributor.author	Terekhov S.
dc.contributor.author	Palikov V.
dc.contributor.author	Palikova Y.
dc.contributor.author	Dyachenko I.
dc.contributor.author	Shamborant O.
dc.contributor.author	Smirnov I.
dc.contributor.author	Masson P.
dc.contributor.author	Gabibov A.
dc.date.accessioned	2018-04-05T07:08:52Z
dc.date.available	2018-04-05T07:08:52Z
dc.date.issued	2017
dc.identifier.issn	0007-4888
dc.identifier.uri	http://dspace.kpfu.ru/xmlui/handle/net/129380
dc.description.abstract	© 2017, Springer Science+Business Media, LLC. We present a procedure for optimizing the expression of recombinant tetrameric butyrylcholinesterase that enables large-scale production with the yield > 30 mg/liter ( > 90 mg/roller bottle). Intravenous injection of the preparation significantly increased survival and decreased the severity of symptoms of poisoning with paraoxon, an organophosphorus toxin.
dc.relation.ispartofseries	Bulletin of Experimental Biology and Medicine
dc.subject	biological drug
dc.subject	organophosphate toxins
dc.subject	paraoxon
dc.subject	prevention of poisoning
dc.subject	tetrameric recombinant human butyrylcholinesterase
dc.title	Application of Tetrameric Recombinant Human Butyrylcholinesterase as a Biopharmaceutical for Amelioration of Symptoms of Acute Organophosphate Poisoning
dc.type	Article
dc.relation.ispartofseries-issue	4
dc.relation.ispartofseries-volume	163
dc.collection	Публикации сотрудников КФУ
dc.relation.startpage	430
dc.source.id	SCOPUS00074888-2017-163-4-SID85028765096

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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.