Научные публикации в Scopus
https://dspace.kpfu.ru/xmlui/handle/net/92871
Публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus2024-03-19T11:07:13ZRelationship between the blood levels of inflammatory cytokines and the number of circulating tumor cells with response to standard chemotherapy in patients with ovarian cancer
https://dspace.kpfu.ru/xmlui/handle/net/170540
Relationship between the blood levels of inflammatory cytokines and the number of circulating tumor cells with response to standard chemotherapy in patients with ovarian cancer
Gening S.O.; Rizvanov A.A.; Abakumova T.V.; Dolgova D.R.; Gafurbaeva D.U.; Rakhmatullina A.R.; Antoneeva I.I.; Gening T.P.
Introduction. Serum chemokines are inflammatory mediators, which role is shown in the occurrence and progression of a number of malignant tumors. Produced by white blood cells, stem cells, tumor and endothelial cells, chemokines control their movement and positioning. Chronic inflammation underlies the progression of ovarian cancer (OC). This increases the likelihood of chemokines stimulating or blocking tumor progression. The aim of the study was to evaluate the relationship between the blood levels of inflammatory cytokines in blood and the number of circulating tumor cells (CTCs) with the response to standard chemotherapy (CT) in patients with cancer. Material and Methods. In patients with primary OC before and after 2–4 courses of chemotherapy and in patients with benign ovarian tumors (as a control), serum levels of CCL2, CCL3, CCL4, CXCL8 and CX3CL1 were evaluated by multiplex xMAP analysis. The amount of CTCs (population CD45-/ Epcam+/CK+) was determined using a flow cytometer. Patients with ovarian cancer were divided into 3 groups according to the platinum sensitivity criterion of GCJG 4th, and progression-free interval (PFI) was determined. Results. It was found that the levels of CCL2, CCL3, CCL4, CXCL8, and CX3CL1 in case of OC did not significantly differ from that in the control, strongly negatively correlated with age (except for the CCL2 level). CT significantly increased the level of CCL2 in the group of refractory OC; of CCL3 – in the group of sensitive OC, of CCL4 – in the groups of resistant and sensitive OC, and CXCL8 level increased in the groups with resistant and sensitive OC and decreased in the group of refractory OC. The number of CTCs in patients with OC was significantly higher than in the control. After CT, a decrease in the amount of CTCs strongly and significantly correlated with a decrease in the level of CX3CL1 in the groups of refractory and sensitive OC. The maximum PFI occurred with an increase in serum levels of CCL3, CXCL8, a decrease in CCL4 and a constant level of CX3CL1. Conclusion. Thus, no significant differences in the levels of CCL2, CCL3, CCL4, and IL-8 between patients with OC and control groups were found. The levels of chemokines studied and the amount of CTCs differed in the groups divided by the tumor sensitivity to CT. We observed significant correlations between the amount of CTCs and the level of CX3CL1 in the group of platinum-sensitive OC.
2021-01-01T00:00:00ZThe names of the diseases in the written language of the Siberian Tatars of the 19th - early 20th centuries (based on the mosque books of the Tobolsk province)
https://dspace.kpfu.ru/xmlui/handle/net/170539
The names of the diseases in the written language of the Siberian Tatars of the 19th - early 20th centuries (based on the mosque books of the Tobolsk province)
Fayzullina G.C.; Kadirova E.K.; Maslovskaya L.Z.
The paper raises the question of studying the written heritage of the indigenous Turkic-speaking population of Western Siberia - the Siberian Tatars. The material of the study is the metric book “on a note of the dead” written in Arabic graphics in the Old Tatar language. The chronological framework of the study is the period from the 1830s to the beginning of the 20th century. The lexico-semantic classification of the names of diseases distinguishes four main groups: records containing the name of any part of the body/organ; records containing the name of the reaction/condition of the body; records containing the name of any change (internal or external) in the body/neoplasm on the body; names of diseases referring to a religious worldview. From the point of view of the structure, it was revealed that the names of diseases consist of two to three components, with the main semantic load in the first word. It was established that in 73.6 % of cases, the first component has a Turkic basis, and in 26.3 %, it was borrowed. The authors conclude that most lexemes in the modern pronunciation (or form) are widely used both in the Tatar literary language and in the dialects of the Siberian Tatars. The semantic dialectisms were identified, and lexemes used only in mosque books and dating back to foreign roots - Arabic or Persian - were distinguished.
2021-01-01T00:00:00ZAssessment of the geological factors influence on the oil-productive of terrigenous reservoirs of the Vereyian horizon of the Melekess depression
https://dspace.kpfu.ru/xmlui/handle/net/170538
Assessment of the geological factors influence on the oil-productive of terrigenous reservoirs of the Vereyian horizon of the Melekess depression
Korolev E.A.; Eskin A.A.; Khuzina A.F.; Barieva E.R.; Ilaeva A.A.
The article presents study results of terrigenous reservoirs of the Vereiskian horizon of Tatarstan. The sandstones and silty sandstones are composed by grains of quartz, feldspars, clay minerals and organic remains cemented with calcite. Rocks were formed under the conditions of marine paleobasin coastal part with normal salinity. The migrated aggressive solutions partially leached out the carbonate cement from sediment, realizing the reservoir-filtration potential inherent in rocks. The oil fluids that filled the pore space practically did not interact in any way with the mineral skeleton of terrigenous reservoirs at the chemical level. Thus, the influence of the rocks mineral component on the properties of oils is completely excluded. In oil-saturated reservoirs, from which good oil inflows are obtained, light fractions of hydrocarbons prevail, boiling away at temperatures of 200-320°C. In the reservoir rocks, from where the watered oils are obtained, there are medium and heavy fractions of hydrocarbons, boiling at temperatures of 320-450°C. In unproductive sandy reservoirs with immobile viscous oil, only heavy fractions of hydrocarbons, which boiling at temperatures above 450°C, prevail. Thus, the oil recovery of terrigenous reservoirs is determined not by the composition of host rocks, but by the degree of oils oxidation contained in them.
2021-01-01T00:00:00ZElectric Vehicle Chassis Simulation Model in MATLAB/Simulink
https://dspace.kpfu.ru/xmlui/handle/net/170537
Electric Vehicle Chassis Simulation Model in MATLAB/Simulink
Martyanov A.S.; Shepelev V.D.; Mavrin V.G.
Nowadays, there has been an active growth of interest in the development and use of vehicles based on the utilization of electric energy. Electric vehicles are actively being studied and then introduced into everyday life. A large number of studies are aimed at improving the existing design of vehicle components, units, and mechanisms. In this paper, we study a simulation model of an electric vehicle moving along a road with an irregular profile. We use the example of an electric vehicle chassis equipped with an electric motor and an energy storage device, taking into account the change in energy spent on moving along the road, considering the rises and descents, as well as the influence of speed modes under given conditions. The model takes into account air resistance and friction forces acting on the units of the car during movement. The model is implemented in the MATLAB/Simulink environment and can be useful in determining the electric drive parameters of an electric vehicle, analysing the electrical system, and studying the efficiency of vehicle operation.
2021-01-01T00:00:00Z