Browsing by Subject "RING domain of TRAF6"

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Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6

Qi Y.; Pradipta A.; Li M.; Zhao X.; Lu L.; Fu X.; Wei J.; Hsung R.; Tanaka K.; Zhou L. (2017)

© 2017 The Author(s).Background: Cancer cells are known to over-express TRAF6 that is critical for both AKT and TAK1 activations. The Really Interesting New Gene (RING) domain of TRAF6 is believed to be responsible for the ...
In vitro and in vivo cancer cell apoptosis triggered by competitive binding of Cinchona alkaloids to the RING domain of TRAF6

Qi Y.; Zhao X.; Chen J.; Pradipta A.; Wei J.; Ruan H.; Zhou L.; Hsung R.; Tanaka K. (2019)

© 2018 Japan Society for Bioscience, Biotechnology, and Agrochemistry TRAF6 is highly expressed in many tumors and plays an important role in the immune system. The aim of this study is to confirm anti-tumor activities of ...

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