Browsing by Author "Petrushanko I."

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  • Binase cleaves cellular noncoding RNAs and affects coding mRNAs 
    Mitkevich V.; Tchurikov N.; Zelenikhin P.; Petrushanko I.; Makarov A.; Ilinskaya O. (2010)
    Bacterial RNases are promising tools for the development of anticancer drugs. Neoplastic transformation leads to enhanced accumulation of rRNA and tRNA, and altered expression of regulatory noncoding RNAs. Cleavage of RNA ...
  • Binase induces apoptosis of transformed myeloid cells and does not induce T-cell immune response 
    Ilinskaya O.; Zelenikhin P.; Petrushanko I.; Mitkevich V.; Prassolov V.; Makarov A. (2007)
    Microbial RNases along with such animal RNases as onconase and BS-RNase are a promising basis for developing new antitumor drugs. We have shown that the Bacillus intermedius RNase (binase) induces selective apoptosis of ...
  • Hydration of methemoglobin studied by in silico modeling and dielectric spectroscopy 
    Latypova L.; Puzenko A.; Poluektov Y.; Anashkina A.; Petrushanko I.; Bogdanova A.; Feldman Y. (2021)
    The hemoglobin concentration of 35 g/dl of human red blood cells is close to the solubility threshold. Using microwave dielectric spectroscopy, we have assessed the amount of water associated with hydration shells of ...
  • Oncogenic c-kit transcript is a target for binase 
    Mitkevich V.; Petrushanko I.; Kretova O.; Spirin P.; Zelenikhin P.; Prassolov V.; Tchurikov N.; Ilinskaya O.; Makarov A. (2010)
    Mutational activation of c-Kit receptor tyrosine kinase is common in acute myelogenous leukemia. One such activating point mutation is the N822K replacement in the c-Kit protein. Here we investigate the selective cytotoxic ...
  • Oxygenation state of hemoglobin defines dynamics of water molecules in its vicinity 
    Latypova L.; Barshtein G.; Puzenko A.; Poluektov Y.; Anashkina A.; Petrushanko I.; Fenk S.; Bogdanova A.; Feldman Y. (2020)
    © 2020 Author(s). This study focuses on assessing the possible impact of changes in hemoglobin (Hb) oxygenation on the state of water in its hydration shell as it contributes to red blood cell deformability. Microwave ...
  • Ribonuclease binase apoptotic signature in leukemic Kasumi-1 cells 
    Mitkevich V.; Kretova O.; Petrushanko I.; Burnysheva K.; Sosin D.; Simonenko O.; Ilinskaya O.; Tchurikov N.; Makarov A. (2013)
    Cytotoxic exogenous RNases triggering apoptotic response in malignant cells have potential as anticancer drugs; surprisingly, detailed characterization of the RNase-induced apoptosis has not been conducted so far. Here we ...
  • Sensitivity of acute myeloid leukemia Kasumi-1 cells to binase toxic action depends on the expression of KIT and AML1-ETO oncogenes 
    Mitkevich V.; Petrushanko I.; Spirin P.; Fedorova T.; Kretova O.; Tchurikov N.; Prassolov V.; Ilinskaya O.; Makarov A. (2011)
    Some RNases selectively attack malignant cells, triggering an apoptotic response and therefore are considered as alternative chemotherapeutic drugs. Here, we studied the effects of Bacillus intermedius RNase (binase) on ...

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