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Browsing by Author "Nemukhin A."

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Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad

Grigorenko B.; Novichkova D.; Lushchekina S.; Zueva I.; Schopfer L.; Nemukhin A.; Varfolomeev S.; Lockridge O.; Masson P. (2019)

© 2019 Elsevier B.V. A computer-designed mutant of human butyrylcholinesterase (BChE), N322E/E325G, with a novel catalytic triad was made. The catalytic triad of the wild-type enzyme (S198·H438·E325) was replaced by ...
Molecular polymorphism of human enzymes as the basis of individual sensitivity to drugs. Supercomputer-assisted modeling as a tool for analysis of structural changes and enzymatic activity of proteins

Varfolomeev S.; Lushchekina S.; Nemukhin A.; Kulakova A.; Kots E.; Makhaeva G.; Delacour H.; Lockridge O.; Masson P. (2016)

© 2016, Springer Science+Business Media New York.The nature of individual sensitivity to drugs associated with molecular polymorphism of human enzymes is discussed. The influence of molecular polymorphism on the activity ...
Understanding the non-catalytic behavior of human butyrylcholinesterase silent variants: Comparison of wild-type enzyme, catalytically active Ala328Cys mutant, and silent Ala328Asp variant

Lushchekina S.; Nemukhin A.; Varfolomeev S.; Masson P. (2016)

© 2016 Elsevier Ireland LtdConformational dynamics of wild-type human butyrylcholinesterase (BChE), two mutants of residue Ala328, the catalytically active Ala328Cys, and the catalytically inactive (silent) Ala328Asp, and ...
Understanding the non-catalytic behavior of human butyrylcholinesterase silent variants: Comparison of wild-type enzyme, catalytically active Ala328Cys mutant, and silent Ala328Asp variant

Lushchekina S.; Nemukhin A.; Varfolomeev S.; Masson P. (2016)

© 2016 Elsevier Ireland Ltd.Conformational dynamics of wild-type human butyrylcholinesterase (BChE), two mutants of residue Ala328, the catalytically active Ala328Cys, and the catalytically inactive (silent) Ala328Asp, and ...

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Browsing by Author "Nemukhin A."

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