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Browsing by Author "Khazak V."

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A novel HSP90 inhibitor-drug conjugate to SN38 is highly effective in small cell lung cancer

Gaponova A.; Nikonova A.; Deneka A.; Kopp M.; Kudinov A.; Skobeleva N.; Khazak V.; Ogawa L.; Cai K.; Duncan K.; Duncan J.; Egleston B.; Proia D.; Boumber Y.; Golemis E. (2016)

©2016 AACR.Purpose: Small cell lung cancer (SCLC) is a highly aggressive disease representing 12% to 13% of total lung cancers, with median survival of <2 years. No targeted therapies have proven effective in SCLC. Although ...
Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer

Gabitova-Cornell L.; Surumbayeva A.; Peri S.; Franco-Barraza J.; Restifo D.; Weitz N.; Ogier C.; Goldman A.R.; Hartman T.R.; Francescone R.; Tan Y.; Nicolas E.; Shah N.; Handorf E.A.; Cai K.Q.; O'Reilly A.M.; Sloma I.; Chiaverelli R.; Moffitt R.A.; Khazak V.; Fang C.Y.; Golemis E.A.; Cukierman E.; Astsaturov I. (2020)

© 2020 Elsevier Inc. Oncogenic transformation alters lipid metabolism to sustain tumor growth. We define a mechanism by which cholesterol metabolism controls the development and differentiation of pancreatic ductal ...
CRISPR/Cas9 genome-wide loss-of-function screening identifies druggable cellular factors involved in sunitinib resistance in renal cell carcinoma

Makhov P.; Sohn J.A.; Serebriiskii I.G.; Fazliyeva R.; Khazak V.; Boumber Y.; Uzzo R.G.; Kolenko V.M. (2020)

© 2020, The Author(s), under exclusive licence to Cancer Research UK. Background: Multi-targeted tyrosine kinase inhibitors (TKIs) are the standard of care for patients with advanced clear cell renal cell carcinoma (ccRCC). ...
Screening of conditionally reprogrammed patient-derived carcinoma cells identifies ERCC3-MYC interactions as a target in pancreatic cancer

Beglyarova N.; Banina E.; Zhou Y.; Mukhamadeeva R.; Andrianov G.; Bobrov E.; Lysenko E.; Skobeleva N.; Gabitova L.; Restifo D.; Pressman M.; Serebriiskii I.; Hoffman J.; Paz K.; Behrens D.; Khazak V.; Jablonski S.; Golemis E.; Weiner L.; Astsaturov I. (2016)

©2016 AACR.Purpose: Even when diagnosed prior to metastasis, pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with almost 90% lethality, emphasizing the need for new therapies optimally targeting the ...

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Browsing by Author "Khazak V."

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