Browsing by Author "Gladkikh D."

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A novel expression cassette delivers efficient production of exclusively tetrameric human butyrylcholinesterase with improved pharmacokinetics for protection against organophosphate poisoning

Terekhov S.; Smirnov I.; Bobik T.; Shamborant O.; Zenkova M.; Chernolovskaya E.; Gladkikh D.; Murashev A.; Dyachenko I.; Palikov V.; Palikova Y.; Knorre V.; Belogurov A.; Ponomarenko N.; Blackburn G.; Masson P.; Gabibov A. (2015)

© 2015 Published by Elsevier B.V. Butyrylcholinesterase is a stoichiometric bioscavenger against poisoning by organophosphorus pesticides and nerve agents. The low level of expression and extremely rapid clearance of ...
Excessive labeling technique provides a highly sensitive fluorescent probe for real-time monitoring of biodegradation of biopolymer pharmaceuticals in vivo

Terekhov S.; Smirnov I.; Shamborant O.; Zenkova M.; Chernolovskaya E.; Gladkikh D.; Murashev A.; Dyachenko I.; Knorre V.; Belogurov A.; Ponomarenko N.; Deyev S.; Vlasov V.; Gabibov A. (2014)

© 2014 Park-media, Ltd. Recombinant proteins represent a large sector of the biopharma market. Determination of the main elimination pathways raises the opportunities to significantly increase their half-lives in vivo. ...

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