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Browsing by Author "Gabibov A."

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A novel expression cassette delivers efficient production of exclusively tetrameric human butyrylcholinesterase with improved pharmacokinetics for protection against organophosphate poisoning

Terekhov S.; Smirnov I.; Bobik T.; Shamborant O.; Zenkova M.; Chernolovskaya E.; Gladkikh D.; Murashev A.; Dyachenko I.; Palikov V.; Palikova Y.; Knorre V.; Belogurov A.; Ponomarenko N.; Blackburn G.; Masson P.; Gabibov A. (2015)

© 2015 Published by Elsevier B.V. Butyrylcholinesterase is a stoichiometric bioscavenger against poisoning by organophosphorus pesticides and nerve agents. The low level of expression and extremely rapid clearance of ...
Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF- α and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients

Lomakin Y.; Belogurov A.; Glagoleva I.; Stepanov A.; Zakharov K.; Okunola J.; Smirnov I.; Genkin D.; Gabibov A. (2016)

© 2016 Yakov Lomakin et al.We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic encephalomyelitis (EAE). Within the frames ...
Application of Tetrameric Recombinant Human Butyrylcholinesterase as a Biopharmaceutical for Amelioration of Symptoms of Acute Organophosphate Poisoning

Terekhov S.; Palikov V.; Palikova Y.; Dyachenko I.; Shamborant O.; Smirnov I.; Masson P.; Gabibov A. (2017)

© 2017, Springer Science+Business Media, LLC. We present a procedure for optimizing the expression of recombinant tetrameric butyrylcholinesterase that enables large-scale production with the yield > 30 mg/liter ( > 90 ...
CD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human, Proof-of-Concept Dose-Escalation Study

Belogurov A.; Zakharov K.; Lomakin Y.; Surkov K.; Avtushenko S.; Kruglyakov P.; Smirnov I.; Makshakov G.; Lockshin C.; Gregoriadis G.; Genkin D.; Gabibov A.; Evdoshenko E. (2016)

© 2016, The Author(s).Previously, we showed that CD206-targeted liposomal delivery of co-encapsulated immunodominant myelin basic protein (MBP) sequences MBP46–62, MBP124–139 and MBP147–170 (Xemys) suppressed experimental ...
CD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human, Proof-of-Concept Dose-Escalation Study

Belogurov A.; Zakharov K.; Lomakin Y.; Surkov K.; Avtushenko S.; Kruglyakov P.; Smirnov I.; Makshakov G.; Lockshin C.; Gregoriadis G.; Genkin D.; Gabibov A.; Evdoshenko E. (2016)

© 2016 The Author(s)Previously, we showed that CD206-targeted liposomal delivery of co-encapsulated immunodominant myelin basic protein (MBP) sequences MBP46–62, MBP124–139 and MBP147–170 (Xemys) suppressed experimental ...
Chemical polysialylation and in vivo tetramerization improve pharmacokinetic characteristics of recombinant human butyrylcholinesterase-based bioscavengers

Terekhov S.; Smirnov I.; Shamborant O.; Bobik T.; Ilyushin D.; Murashev A.; Dyachenko I.; Palikov V.; Knorre V.; Belogurov A.; Ponomarenko N.; Kuzina E.; Genkin D.; Masson P.; Gabibov A. (2015)

© 2015 Park-media, Ltd. Organophosphate toxins (OPs) are the most toxic low-molecular compounds. The extremely potent toxicity of OPs is determined by their specificity toward the nerve system. Human butyrylcholinesterase ...
Chemical polysialylation of recombinant human proteins

Smirnov I.; Vorobiev I.; Belogurov A.; Genkin D.; Deyev S.; Gabibov A. (2015)

© Springer Science+Business Media New York 2015. All right reserved. Design of drug with prolonged therapeutic action is one of the rapid developing fields of modern medical science and required implementation of different ...
Death receptors: New opportunities in cancer therapy

Ukrainskaya V.; Stepanov A.; Glagoleva I.; Knorre V.; Belogurov A.; Gabibov A. (2017)

© 2017 Park-media, Ltd. This article offers a detailed review of the current approaches to anticancer therapy that target the death receptors of malignant cells. Here, we provide a comprehensive overview of the structure ...
Deimination of the myelin basic protein decelerates its proteasome-mediated metabolism

Kuzina E.; Kudriaeva A.; Glagoleva I.; Knorre V.; Gabibov A.; Belogurov A. (2016)

© 2016, Pleiades Publishing, Ltd.Deimination of myelin basic protein (MBP) by peptidylarginine deiminase (PAD) prevents its binding to the proteasome and decelerates its degradation by the proteasome in mammalian cells. ...
Development of a recombinant immunotoxin for the immunotherapy of autoreactive lymphocytes expressing MOG-specific BCRs

Stepanov A.; Belyy A.; Kasheverov I.; Rybinets A.; Dronina M.; Dyachenko I.; Murashev A.; Knorre V.; Sakharov D.; Ponomarenko N.; Tsetlin V.; Tonevitsky A.; Deyev S.; Belogurov A.; Gabibov A. (2016)

© 2016, Springer Science+Business Media Dordrecht.Objective: Myelin oligodendrocyte glycoprotein (MOG) is one of the major autoantigens in multiple sclerosis (MS), therefore selective depletion of autoreactive lymphocytes ...
Development of a recombinant immunotoxin for the immunotherapy of autoreactive lymphocytes expressing MOG-specific BCRs

Stepanov A.; Belyy A.; Kasheverov I.; Rybinets A.; Dronina M.; Dyachenko I.; Murashev A.; Knorre V.; Sakharov D.; Ponomarenko N.; Tsetlin V.; Tonevitsky A.; Deyev S.; Belogurov A.; Gabibov A. (2016)

© 2016 Springer Science+Business Media DordrechtObjective: Myelin oligodendrocyte glycoprotein (MOG) is one of the major autoantigens in multiple sclerosis (MS), therefore selective depletion of autoreactive lymphocytes ...
Development of a recombinant immunotoxin for the immunotherapy of autoreactive lymphocytes expressing MOG-specific BCRs

Stepanov A.; Belyy A.; Kasheverov I.; Rybinets A.; Dronina M.; Dyachenko I.; Murashev A.; Knorre V.; Sakharov D.; Ponomarenko N.; Tsetlin V.; Tonevitsky A.; Deyev S.; Belogurov A.; Gabibov A. (2016)

OBJECTIVE: Myelin oligodendrocyte glycoprotein (MOG) is one of the major autoantigens in multiple sclerosis (MS), therefore selective depletion of autoreactive lymphocytes exposing MOG-specific B cell receptors (BCRs) would ...
Diagnostics of autoimmune neurodegeneration using fluorescent probing

Lomakin Y.; Kudriaeva A.; Kostin N.; Terekhov S.; Kaminskaya A.; Chernov A.; Zakharova M.; Ivanova M.; Simaniv T.; Telegin G.; Gabibov A.; Belogurov A. (2018)

© 2018, The Author(s). The discovery of antibody-mediated catalysis was a breakthrough that showed antibody function is not limited to specific binding interactions, and that immunoglobulins (Igs) may also chemically ...
Differential Diagnostics of Active Progressing Multiple Sclerosis Using a Fluorescent Biomarker with Resonance Energy Transfer

Lomakin Y.; Kudryaeva A.; Kostin N.; Terekhov S.; Kaminskaya A.; Zakharova M.; Ivanova M.; Simaniv T.; Gabibov A.; Belogurov A. (2019)

© 2019, Springer Science+Business Media, LLC, part of Springer Nature. Previous data showed that myelin-reactive autoantibodies found in patients with multiple sclerosis and mice with experimental autoimmune encephalomyelitis ...
Divergent immunomodulation capacity of individual myelin peptides-components of liposomal therapeutic against multiple sclerosis

Ivanova V.; Khaiboullina S.; Gomzikova M.; Martynova E.; Ferreira A.; Garanina E.; Sakhapov D.; Lomakin Y.; Khaibullin T.; Granatov E.; Khabirov F.; Rizvanov A.; Gabibov A.; Belogurov A. (2017)

© 2017 Ivanova, Khaiboullina, Gomzikova, Martynova, Ferreira, Garanina, Sakhapov, Lomakin, Khaibullin, Granatov, Khabirov, Rizvanov, Gabibov and Belogurov. Multiple sclerosis (MS) is an autoimmune disease characterized by ...
Evolution of inhibitor-resistant natural mutant forms of HIV-1 protease probed by pre-steady state kinetic analysis

Zakharova M.; Kuznetsova A.; Kaliberda E.; Dronina M.; Kolesnikov A.; Kozyr A.; Smirnov I.; Rumsh L.; Fedorova O.; Knorre D.; Gabibov A.; Kuznetsov N. (2017)

© 2017 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM) Pre-steady state kinetic analysis of mechanistic features of substrate binding and processing is crucial for insight into the evolution ...
Excessive labeling technique provides a highly sensitive fluorescent probe for real-time monitoring of biodegradation of biopolymer pharmaceuticals in vivo

Terekhov S.; Smirnov I.; Shamborant O.; Zenkova M.; Chernolovskaya E.; Gladkikh D.; Murashev A.; Dyachenko I.; Knorre V.; Belogurov A.; Ponomarenko N.; Deyev S.; Vlasov V.; Gabibov A. (2014)

© 2014 Park-media, Ltd. Recombinant proteins represent a large sector of the biopharma market. Determination of the main elimination pathways raises the opportunities to significantly increase their half-lives in vivo. ...
Exposure to the Epstein-Barr viral antigen latent membrane protein 1 induces myelin-reactive antibodies in vivo

Lomakin Y.; Arapidi G.; Chernov A.; Ziganshin R.; Tcyganov E.; Lyadova I.; Butenko I.; Osetrova M.; Ponomarenko N.; Telegin G.; Govorun V.; Gabibov A.; Belogurov A. (2017)

© 2017 Lomakin, Arapidi, Chernov, Ziganshin, Tcyganov, Lyadova, Butenko, Osetrova, Ponomarenko, Telegin, Govorun, Gabibov and Belogurov. Multiple sclerosis (MS) is an autoimmune chronic inflammatory disease of the central ...
Expression of DNA-Encoded Antidote to Organophosphorus Toxins in the Methylotrophic Yeast Pichia Pastoris

Terekhov S.; Bobik T.; Mokrushina Y.; Stepanova A.; Aleksandrova N.; Smirnov I.; Belogurov A.; Ponomarenko N.; Gabibov A. (2016)

© 2016, Pleiades Publishing, Inc.A platform for the cloning and expression of active human butyrylcholinesterase (BuChE) in the yeast Pichia рastoris is first presented. Genetic constructs for BuChE gene expression, ...
Glatiramer Acetate and Nanny Proteins Restrict Access of the Multiple Sclerosis Autoantigen Myelin Basic Protein to the 26S Proteasome

Kuzina E.; Kudriaeva A.; Smirnov I.; Dubina M.; Gabibov A.; Belogurov A. (2014)

© 2014 Ekaterina Kuzina et al. We recently showed that myelin basic protein (MBP) is hydrolyzed by 26S proteasome without ubiquitination. The previously suggested concept of charge-mediated interaction between MBP and the ...

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Browsing by Author "Gabibov A."

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