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Browsing by Author "Chulpanova D.S."

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Contribution of multipotent mesenchymal stromal cells in the tumor microenvironment and carcinogenesis

Tazetdinova L.G.; Mullagulova A.I.; Solovyeva V.V.; Chulpanova D.S.; Kitaeva K.V.; Rizvanov A.A. (2021)

Carcinogenesis is a complex and dynamic process, an important part of which is the formation of the tumor microenvironment, which is an integral part of malignant tumors and plays an important role in their progression. ...
Cytochalasin B-Induced membrane vesicles from human mesenchymal stem cells overexpressing IL2 are able to stimulate CD8+ T-Killers to kill human triple negative breast cancer cells

Chulpanova D.S.; Gilazieva Z.E.; Kletukhina S.K.; Aimaletdinov A.M.; Garanina E.E.; James V.; Rizvanov A.A.; Solovyeva V.V. (2021)

Simple Summary: Almost all human cells release extracellular vesicles participating in intercellular communication. Extracellular vesicles are rounded structures surrounded by the cytoplasmic membrane, which embody cytoplasmic ...
Cytochalasin B-induced membrane vesicles from human mesenchymal stem cells overexpressing TRAIL, PTEN and IFN-β1 can kill carcinoma cancer cells

Chulpanova D.S.; Gilazieva Z.E.; Akhmetzyanova E.R.; Kletukhina S.K.; Rizvanov A.A.; Solovyeva V.V. (2021)

Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) are of interest as a new vector for the delivery of therapeutic agents into the tumor microenvironment. Cell-free EV-based therapy has a number of ...
Human mesenchymal stem cells overexpressing interleukin 2 can suppress proliferation of neuroblastoma cells in co-culture and activate mononuclear cells in vitro

Chulpanova D.S.; Solovyeva V.V.; James V.; Arkhipova S.S.; Gomzikova M.O.; Garanina E.E.; Akhmetzyanova E.R.; Tazetdinova L.G.; Khaiboullina S.F.; Rizvanov A.A. (2020)

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. High-dose recombinant interleukin 2 (IL2) therapy has been shown to be successful in renal cell carcinoma and metastatic melanoma. However, systemic administration ...
Inflammatory Bowel Disease-Associated Changes in the Gut: Focus on Kazan Patients

Lo Sasso G.; Khachatryan L.; Kondylis A.; Battey J.N.D.; Sierro N.; Danilova N.A.; Grigoryeva T.V.; Markelova M.I.; Khusnutdinova D.R.; Laikov A.V.; Salafutdinov I.I.; Romanova Y.D.; Siniagina M.N.; Vasiliev I.Y.; Boulygina E.A.; Solovyeva V.V.; Garanina E.E.; Kitaeva K.V.; Ivanov K.Y.; Chulpanova D.S.; Kletenkov K.S.; Valeeva A.R.; Odintsova A.K.; Ardatskaya M.D.; Abdulkhakov R.A.; Ivanov N.V.; Peitsch M.C.; Hoeng J.; Abdulkhakov S.R. (2021)

Background: Several studies have highlighted the role of host-microbiome interactions in the pathogenesis of inflammatory bowel disease (IBD), resulting in an increasing amount of data mainly focusing on Western patients. ...
Metachromatic Leukodystrophy: Diagnosis, Modeling, and Treatment Approaches

Shaimardanova A.A.; Chulpanova D.S.; Solovyeva V.V.; Mullagulova A.I.; Kitaeva K.V.; Allegrucci C.; Rizvanov A.A. (2020)

© Copyright © 2020 Shaimardanova, Chulpanova, Solovyeva, Mullagulova, Kitaeva, Allegrucci and Rizvanov. Metachromatic leukodystrophy is a lysosomal storage disease, which is characterized by damage of the myelin sheath ...
Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy

Chulpanova D.S.; Kitaeva K.V.; Green A.R.; Rizvanov A.A.; Solovyeva V.V. (2020)

© Copyright © 2020 Chulpanova, Kitaeva, Green, Rizvanov and Solovyeva. Cytokine-based immunotherapy is a promising field in the cancer treatment, since cytokines, as proteins of the immune system, are able to modulate the ...
Mouse tumor models for advanced cancer immunotherapy

Chulpanova D.S.; Kitaeva K.V.; Rutland C.S.; Rizvanov A.A.; Solovyeva V.V. (2020)

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Recent advances in the development of new methods of cancer immunotherapy require the production of complex cancer animal models that reliably reflect the complexity ...
Recombinant histone H1.3 inhibits orthohantavirus infection in vitro

Chulpanova D.S.; Solovyeva V.V.; Isaeva G.S.; St. Jeor S.; Khaiboullina S.F.; Rizvanov A.A. (2020)

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Histones are proteins participating in DNA packaging. Despite this limited function, histones were shown to have antiviral activity. Histone H1.3 has ...
Serum cytokine profile, beta-hexosaminidase a enzymatic activity and gm<inf>2</inf> ganglioside levels in the plasma of a tay-sachs disease patient after cord blood cell transplantation and curcumin administration: A case report

Shaimardanova A.A.; Chulpanova D.S.; Solovyeva V.V.; Garanina E.E.; Salafutdinov I.I.; Laikov A.V.; Kursenko V.V.; Chakrabarti L.; Zakharova E.Y.; Bukina T.M.; Baydakova G.V.; Rizvanov A.A. (2021)

Tay-Sachs disease (TSD) is a progressive neurodegenerative disorder that occurs due to a deficiency of a β hexosaminidase A (HexA) enzyme, resulting in the accumulation of GM2 gangliosides. In this work, we analyzed the ...
Tay-Sachs disease: Diagnostic, modeling and treatment approaches

Solovyeva V.V.; Shaimardanova A.A.; Chulpanova D.S.; Kitaeva K.V.; Rizvanov A.A. (2020)

© 2020, Human Stem Cell Institute. All rights reserved. Tay-Sachs disease (OMIM 272800) belongs to the group of autosomal-recessive disorders, caused by β-hexosaminidase A (HexA) enzyme deficiency, resulting in GM2-ganglioside ...

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Browsing by Author "Chulpanova D.S."

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