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Browsing by Author "Bitler B."

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BET Bromodomain Inhibition Synergizes with PARP Inhibitor in Epithelial Ovarian Cancer

Karakashev S.; Zhu H.; Yokoyama Y.; Zhao B.; Fatkhutdinov N.; Kossenkov A.; Wilson A.; Simpkins F.; Speicher D.; Khabele D.; Bitler B.; Zhang R. (2017)

© 2017 The Author(s) PARP inhibition is known to be an effective clinical strategy in BRCA mutant cancers, but PARP inhibition has not been applied to BRCA-proficient tumors. Here, we show the synergy of BET bromodomain ...
HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci

Aird K.; Iwasaki O.; Kossenkov A.; Tanizawa H.; Fatkhutdinov N.; Bitler B.; Le L.; Alicea G.; Yang T.; Johnson F.; Noma K.; Zhang R. (2016)

Cellular senescence is a stable cell growth arrest that is characterized by the silencing of proliferation-promoting genes through compaction of chromosomes into senescence-associated heterochromatin foci (SAHF). Paradoxically, ...
NF-YA underlies EZH2 upregulation and is essential for proliferation of human epithelial ovarian cancer cells

Garipov A.; Li H.; Bitler B.; Thapa R.; Balachandran S.; Zhang R. (2013)

Epithelial ovarian cancer (EOC) accounts for the most gynecologic malignancy-associated deaths in the United States. Enhancer of zeste homolog 2 (EZH2), which silences gene expression through generating trimethylation on ...
Potential therapeutic targets in ARID1A -mutated cancers

Bitler B.; Fatkhutdinov N.; Zhang R. (2015)

© 2015 © 2015 Taylor & Francis. ARID1A is a subunit of the Switch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex that regulates gene expression by controlling gene accessibility. ARID1A shows one of the ...
SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells

Wu S.; Fatkhutdinov N.; Fukumoto T.; Bitler B.; Park P.; Kossenkov A.; Trizzino M.; Tang H.; Zhang L.; Gardini A.; Speicher D.; Zhang R. (2018)

© 2018, The Author(s). Inactivation of the subunits of SWI/SNF complex such as ARID1A is synthetically lethal with inhibition of EZH2 activity. However, mechanisms of de novo resistance to EZH2 inhibitors in cancers with ...

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Browsing by Author "Bitler B."

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