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Browsing by Author "Barreto G."

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A critical role for miR-142 in alveolar epithelial lineage formation in mouse lung development

Shrestha A.; Carraro G.; Nottet N.; Vazquez-Armendariz A.; Herold S.; Cordero J.; Singh I.; Wilhelm J.; Barreto G.; Morty R.; El Agha E.; Mari B.; Chen C.; Zhang J.; Chao C.; Bellusci S. (2019)

© 2019, Springer Nature Switzerland AG. The respiratory epithelium arises from alveolar epithelial progenitors which differentiate into alveolar epithelial type 1 (AT1) and type 2 (AT2) cells. AT2 cells are stem cells in ...
Binase penetration into alveolar epithelial cells does not induce cell death

Cabrera-Fuentes H.; Kalacheva N.; Mukhametshina R.; Zelenikhin P.; Kolpakov A.; Barreto G.; Preissner K.; Ilinskaya O. (2012)

Microbial ribonucleases possess a broad spectrum of biological activities, which demonstrate stimulating properties at low concentrations and cytotoxicity and genotoxicity at high concentrations. Mechanisms of their ...
Binase penetration into alveolar epithelial cells does not induce cell death

Cabrera Fuentes H.; Katacheva N.; Mukhametshina R.; Zelenikhin P.; Kolpakov A.; Barreto G.; Preissner K.; Ilinskaya O. (2012)

Microbial ribonucleases possess a broad spectra of biological activities, demonstrating stimulating properties at low concentrations and cytotoxicity and genotoxicity at high concentrations. The mechanisms of their penetration ...
Case report: Cyclospora cayetanensis: This emerging protozoan pathogen in Mexico

Śanchez-Vega J.; Cabrera-Fuentes H.; Romero-Olmedo A.; Ortiz-Fŕias J.; Sokolina F.; Barreto G. (2014)

A Mexican airline pilot had clinical manifestations of illness after a five-day stay in Lima, Peru. Six months later in Mexico, he was given a diagnosis of infection with Cyclospora cayetanensis by using coproparasitoscopic ...
Direct inhibition of oncogenic KRAS by Bacillus pumilus ribonuclease (binase)

Ilinskaya O.; Singh I.; Dudkina E.; Ulyanova V.; Kayumov A.; Barreto G. (2016)

© 2016 Elsevier B.V.RAS proteins function as molecular switches that transmit signals from cell surface receptors into specific cellular responses via activation of defined signaling pathways (Fang, 2015). Aberrant ...
Epigenetics in lung cancer diagnosis and therapy

Mehta A.; Dobersch S.; Romero-Olmedo A.; Barreto G. (2015)

© 2015, Springer Science+Business Media New York. Lung cancer is the leading cause of cancer-related deaths worldwide. The initiation and progression of lung cancer is the result of the interaction between permanent genetic ...
Functional interactions between scaffold proteins, noncoding RNAs, and genome loci induce liquid-liquid phase separation as organizing principle for 3-dimensional nuclear architecture: implications in cancer

Rubio K.; Dobersch S.; Barreto G. (2019)

The eukaryotic cell nucleus consists of functionally specialized subcompartments. These nuclear subcompartments are biomolecular aggregates built of proteins, transcripts, and specific genome loci. The structure and function ...
Generation and validation of MIR-142 knock out mice

Shrestha A.; Carraro G.; El Agha E.; Mukhametshina R.; Chao C.; Rizvanov A.; Barreto G.; Bellusci S.; Kalinichenko V. (2015)

© 2015 Shrestha et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX

Singh I.; Ozturk N.; Cordero J.; Mehta A.; Hasan D.; Cosentino C.; Sebastian C.; Krüger M.; Looso M.; Carraro G.; Bellusci S.; Seeger W.; Braun T.; Mostoslavsky R.; Barreto G. (2015)

© 2015 IBCB, SIBS, CAS. All rights reserved. The eukaryotic genome is organized into chromatins, the physiological template for DNA-dependent processes including replication, recombination, repair, and transcription. ...
Hmga2 is required for canonical WNT signaling during lung development

Singh I.; Mehta A.; Contreras A.; Boettger T.; Carraro G.; Wheeler M.; Cabrera-Fuentes H.; Bellusci S.; Seeger W.; Braun T.; Barreto G. (2014)

Background: The high-mobility-group (HMG) proteins are the most abundant non-histone chromatin-associated proteins. HMG proteins are present at high levels in various undifferentiated tissues during embryonic development ...
Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia

Chao C.; Moiseenko A.; Kosanovic D.; Rivetti S.; El Agha E.; Wilhelm J.; Kampschulte M.; Yahya F.; Ehrhardt H.; Zimmer K.; Barreto G.; Rizvanov A.; Schermuly R.; Reiss I.; Morty R.; Rottier R.; Bellusci S.; Zhang J. (2019)

© 2018 The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. Bronchopulmonary dysplasia (BPD), characterized by alveoli simplification ...
Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis

Rubio K.; Singh I.; Dobersch S.; Sarvari P.; Günther S.; Cordero J.; Mehta A.; Wujak L.; Cabrera-Fuentes H.; Chao C.; Braubach P.; Bellusci S.; Seeger W.; Günther A.; Preissner K.; Wygrecka M.; Savai R.; Papy-Garcia D.; Dobreva G.; Heikenwalder M.; Savai-Pullamsetti S.; Braun T.; Barreto G. (2019)

© 2019, The Author(s). Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and highly lethal lung disease with unknown etiology and poor prognosis. IPF patients die within 2 years after diagnosis mostly due to ...
MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization

Singh I.; Contreras A.; Cordero J.; Rubio K.; Dobersch S.; Günther S.; Jeratsch S.; Mehta A.; Krüger M.; Graumann J.; Seeger W.; Dobreva G.; Braun T.; Barreto G. (2018)

© 2018 The Author(s). The majority of the eukaryotic genome is transcribed into noncoding RNAs (ncRNAs), which are important regulators of different nuclear processes by controlling chromatin structure. However, the full ...
Non-coding RNAs and nuclear architecture during epithelial-mesenchymal transition in lung cancer and idiopathic pulmonary fibrosis

Rubio K.; Castillo-Negrete R.; Barreto G. (2020)

© 2020 Elsevier Inc. Lung cancer (LC) is the leading cause of cancer-related deaths worldwide. On the other hand, idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung disease showing a prevalence of 20 ...
Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate

Mehta A.; Cordero J.; Dobersch S.; Romero-Olmedo A.; Savai R.; Bodner J.; Chao C.; Fink L.; Guzmán-Díaz E.; Singh I.; Dobreva G.; Rapp U.; Günther S.; Ilinskaya O.; Bellusci S.; Dammann R.; Braun T.; Seeger W.; Gattenlöhner S.; Tresch A.; Günther A.; Barreto G. (2016)

© 2016 The Authors. Published under the terms of the CC BY 4.0 licenseLung cancer (LC) is the leading cause of cancer-related deaths worldwide. Early LC diagnosis is crucial to reduce the high case fatality rate of this ...
Pioneer Factors and Architectural Proteins Mediating Embryonic Expression Signatures in Cancer

Dobersch S.; Rubio K.; Barreto G. (2019)

© 2019 Elsevier Ltd Accumulation of mutations causing aberrant changes in the genome promotes cancer. However, mutations do not occur in every cancer subtype, suggesting additional events that trigger cancer. Chromatin ...
Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus

Dzyurkevich M.; Babkov D.; Shtyrlin N.; Mayka O.; Iksanova A.; Vassiliev P.; Balakin K.; Spasov A.; Tarasov V.; Barreto G.; Shtyrlin Y.; Aliev G. (2017)

© 2017 The Author(s). Glucokinase is one of the promising targets for glucose-lowering agents, and the development of GK activators are now considered as one of the most promising strategies for the treatment of type 2 ...
Quantitative proteome analysis of alveolar type-II cells reveals a connection of integrin receptor subunits beta 2/6 and WNT signaling

Mukhametshina R.; Ruhs A.; Singh I.; Hasan D.; Contreras A.; Mehta A.; Nikam V.; Ahlbrecht K.; Carraro G.; Cabrera-Fuentes H.; Jiang D.; Voswinckel R.; Seeger W.; Bellusci S.; Scharffetter-Kochanek K.; Bagaeva T.; Preissner K.; Boettger T.; Braun T.; Krüger M.; Barreto G. (2013)

Alveolar type-II cells (ATII cells) are lung progenitor cells responsible for regeneration of alveolar epithelium during homeostatic turnover and in response to injury. Characterization of ATII cells will have a profound ...
RNase1 prevents the damaging interplay between extracellular RNA and tumour necrosis factor-α in cardiac ischaemia/reperfusion injury

Cabrera-Fuentes H.; Ruiz-Meana M.; Simsekyilmaz S.; Kostin S.; Inserte J.; Saffarzadeh M.; Galuska S.; Vijayan V.; Barba I.; Barreto G.; Fischer S.; Lochnit G.; Ilinskaya O.; Baumgart-Vogt E.; Böning A.; Lecour S.; Hausenloy D.; Liehn E.; Garcia-Dorado D.; Schlüter K.; Preissner K. (2014)

© Schattauer 2014 Despite optimal therapy, the morbidity and mortality of patients presenting with an acute myocardial infarction (M1) remain significant, and the initial mechanistic trigger of myocardial “ischaemia/reperfusion ...
Validation of Tuba1a as appropriate internal control for normalization of gene expression analysis during mouse lung development

Mehta A.; Dobersch S.; Dammann R.; Bellusci S.; Ilinskaya O.; Braun T.; Barreto G. (2015)

© 2015 by the authors; licensee MDPI, Basel, Switzerland. The expression ratio between the analysed gene and an internal control gene is the most widely used normalization method for quantitative RT-PCR (qRT-PCR) expression ...

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Browsing by Author "Barreto G."

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